Methods We searched the Cochrane Central Register of Controlled Trials and
Epistemonikos, as well as MEDLINE from 1966 till August 2019. Screening of full texts …

Objective To systematically evaluate the efficacy and safety of norepinephrine in the
treatment of septic shock. Methods Literature retrieval of eligible randomized controlled trials …

BACKGROUND Vasopressor administration at an appropriate time is crucial but the optimal
timing remains controversial. RESEARCH QUESTION Does early versus late …

Background The effect of norepinephrine in patients with septic shock remains controversial.
We conducted a meta-analysis to compare the mortality rates and benefits of norepinephrine …

Background The use of vasopressors is vital in septic shock. However, the optimal timing of
treatment remains unclear. Therefore, we aimed to explore the impact of early …

Introduction Septic shock still carries a high mortality rate despite all advances in emergency
and critical care practices. Early interventions have been proven in many aspects to improve …

Received July 30, 2010, and in revised form September 14, 2010. Accepted for publication
September 20, 2010. Background: There is debate as to the vasopressor agent of choice in …

Background Septic shock is associated with high mortality. Aged and multimorbid patients
are not always eligible for intensive care units. Norepinephrine is an accepted treatment for …

Rationale: Recent retrospective evidence suggests the efficacy of early norepinephrine
administration during resuscitation; however, prospective data to support this assertion are …

Objective: We aim to identify the appropriate vasoactive agent in patients with septic shock
who are refractory to optimal doses of norepinephrine. Methods: In this retrospective …