Background Bipolar disorder is a serious and common psychiatric disorder characterized by
manic and depressive mood switches and a relapsing and remitting course. The …

Pharmacogenomics may provide us with the means to expedite treatment for patients with
various psychiatric disorders. Treatment is presently hampered by individual variation in …

This chapter summarizes the current knowledge about the pharmacogenetics and
pharmacogenomics of antidepressant drugs in major depressive disorder (MDD) …

Pharmacogenetics brought the promise of matching individuals with treatments that would
be efficacious while minimizing adverse events. This has been long needed in psychiatry …

Introduction: Pharmacogenetic testing may assist in identifying an individual's risk of
developing a mental illness as well as predict an individual's response to treatment. The …

BACKGROUND: There is wide variation in antidepressant efficacy and tolerability during the
treatment of major depressive disorder, a brain disease associated with significant morbidity …

Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug
selection and dosing to the patient's genetic features. In recent years, several …

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

A long-established hypothesis is that genetic factors contribute to the development of
psychiatric diseases, including common illnesses such as schizophrenia and the affective …

Pharmacogenetic studies of psychotropic drug response have focused on determining the
relationship between variation in specific candidate genes and the positive and adverse …