BACKGROUND: There is wide variation in antidepressant efficacy and tolerability during the
treatment of major depressive disorder, a brain disease associated with significant morbidity …

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

The role of genomics in personalized medicine continues to undergo profound changes, in
step with dramatic technological advances. Ability to sequence the entire human genome …

Neuropsychiatric disorders and dementia represent a major cause of disability and high cost
in developed societies. Most disorders of the central nervous system (CNS) share some …

Bipolar disorder (BD) features heterogenous clinical presentation and course of illness. It
remains unclear how subphenotypes associate with genetic loadings of BD and related …

The field of psychiatry is facing an important paradigm shift in the provision of clinical care
and mental health service organization toward personalization and integration of multimodal …

Pharmacogenetic studies of psychotropic drug response have focused on determining the
relationship between variation in specific candidate genes and the positive and adverse …

A long-established hypothesis is that genetic factors contribute to the development of
psychiatric diseases, including common illnesses such as schizophrenia and the affective …

Mental disorders represent a major public health burden worldwide. This is likely to rise in
the next decade, with the highest increases predicted to occur in low-and middle-income …

Objective The main goal of this work was to identify, describe, characterize, and classify the
scientific evidence regarding the use of pharmacogenomic biomarkers in antidepressant …