Human mitochondrial transcripts contain messenger and ribosomal RNAs flanked by
transfer RNAs (tRNAs), which are excised by mitochondrial RNase (mtRNase) P and Z to …

RNase P is the endonuclease responsible for the 5′ processing of precursor tRNAs (pre-
tRNAs). Unlike the single-subunit protein-only RNase P (PRORP) found in plants or protists …

Mitochondrial RNA polymerase produces long polycistronic precursors that contain the
mRNAs, rRNAs and tRNAs needed for mitochondrial translation. Mitochondrial RNase P (mt …

Summary tRNAs are synthesized as immature precursors, and on their way to functional
maturity, extra nucleotides at their 5′ ends are removed by an endonuclease called RNase …

Mitochondrial polycistronic transcripts are extensively processed to give rise to functional
mRNAs, rRNAs and tRNAs; starting with the release of tRNA elements through 5 …

Transfer RNAs (tRNAs) reach their mature functional form through several steps of
processing and modification. Some nucleotide modifications affect the proper folding of …

Ribonuclease P (RNase P) catalyzes the maturation of the 5′ end of tRNA precursors.
Typically these enzymes are ribonucleoproteins with a conserved RNA component …

Mammalian mitochondrial DNA is transcribed as precursor polycistronic transcripts
containing 13 mRNAs, 2 rRNAs, punctuated by 22 tRNAs. The mechanisms involved in the …

Accurate tRNA processing is crucial for human mitochondrial genome expression, but the
mechanisms of mt-tRNA cleavage and the key enzymes involved in this process are poorly …

Human mitochondrial RNase P does not distinguish itself from other RNase P enzymes by
most of its basic properties. 5′ phosphates on tRNA products, strict dependence on a …