[HTML][HTML] Uveal melanoma: identifying immunological and chemotherapeutic targets to treat metastases

MJ Jager, M Dogrusöz, SE Woodman - Asia-Pacific Journal of …, 2017 - Elsevier
Uveal melanoma is an intraocular malignancy that, depending on its size and genetic make-
up, may lead to metastases in up to 50% of cases. Currently, no therapy has been proven to …

Immunotherapy for uveal melanoma-current knowledge and perspectives

S Kaštelan, AG Antunica, LB Oresković… - Current medicinal …, 2020 - ingentaconnect.com
Uveal melanoma is the most prevalent primary intraocular tumour in adults with the
incidence between five and six cases per million people in the United States and Europe …

Immunotherapies for the treatment of uveal melanoma—history and future

TE Schank, JC Hassel - Cancers, 2019 - mdpi.com
Background: Uveal melanoma is the most common primary intraocular malignancy among
adults. It is, nevertheless, a rare disease, with an incidence of approximately one case per …

Clinical trials in metastatic uveal melanoma: Immunotherapy

M Orloff - Ocular Oncology and Pathology, 2021 - karger.com
Background: Uveal melanoma (UM) is a rare subtype of melanoma that generally has a poor
prognosis once it has metastasized. Clinical trials evaluating immune checkpoint inhibitors …

Immunotherapy of uveal melanoma

JJ Bosch - Current Concepts in Uveal Melanoma, 2012 - karger.com
Uveal melanoma is a malignancy with exceptional features for treatment with
immunotherapy. Primary uveal melanoma can be treated with a variety of therapies that may …

Immunotherapy in uveal melanoma: novel strategies and opportunities for personalized treatment

C Masaoutis, S Kokkali… - Expert opinion on …, 2021 - Taylor & Francis
Introduction Uveal melanoma (UM) is the most common intraocular cancer and represents a
discrete subtype of melanoma. Metastatic disease, which occurs in half of patients, has a …

Protein kinase inhibitor responses in uveal melanoma reflects a diminished dependency on PKC-MAPK signaling

JJ Park, A Stewart, M Irvine, B Pedersen, Z Ming… - Cancer Gene …, 2022 - nature.com
Uveal melanoma (UM) is a rare cancer arising from melanocytes in the uveal tract of the eye.
Despite effective primary treatment, there is no approved therapy for metastatic UM and …

Combined PKC and MEK inhibition for treating metastatic uveal melanoma

MS Sagoo, JW Harbour, J Stebbing, AM Bowcock - Oncogene, 2014 - nature.com
Uveal melanoma (UM) is the most common primary intraocular malignancy and the second
most common form of melanoma. UM has a strong tendency for metastatic disease, and no …

Immunotherapy for uveal melanoma

MP Breazzano, RW Milam Jr, SA Batson… - International …, 2017 - journals.lww.com
Uveal melanoma is the most common primary intraocular tumor in adults. 1 Before the mid-
20th century, enucleation was the mainstay of treatment for uveal melanoma. Although this …

Role of immune checkpoint inhibitors and novel immunotherapies in uveal melanoma

V Jindal - Chinese Clinical Oncology, 2018 - cco.amegroups.org
Uveal melanoma (UM) is one of the rare malignancies, which can be lethal despite local
treatment. Treatment options available now can control UM in early stages, but once it …