AP-1, a transcription factor comprised primarily of Jun and Fos family proteins, regulates
genes involved in proliferation, differentiation and oncogenesis. Previous studies …

A plethora of physiological and pathological stimuli induce and activate a group of DNA
binding proteins that form AP-1 dimers. These proteins include the Jun, Fos and ATF …

The AP-1 transcription factor is a dimeric complex that contains members of the JUN, FOS,
ATF and MAF protein families. AP-1 proteins are primarily considered to be oncogenic, but …

Since its discovery more than two decades ago the involvement of the Activating protein 1
(AP-1) in proliferation, inflammation, differentiation, apoptosis, cellular migration and wound …

The AP‐1 transcription factor (the Jun and Fos proteins) is suspected of playing an important
role in the biology of human cancer. Human epithelial ovarian tumors and cancer cell lines …

Objectives The activator protein-1 (AP-1) is a dimeric transcription factor formed by members
of the Jun and Fos protein family. AP-1 plays a role in a variety of physiological functions …

AP-1 transactivation appears to be required for mouse JB6 cell neoplastic transformation
induced by the tumor promoter TPA or epidermal growth factor (EGF). Exposure to AP-1 …

The AP-1 transcription factor is composed of a mixture of homo-and hetero-dimers formed
between Jun and Fos proteins. The different Jun and Fos family members vary significantly …

Genetically modified mice have provided important insights into the biological functions of
the dimeric transcription factor complex AP-1. Extensive analyses of mice and cells with …

Abstract The activating protein-1 (AP-1) transcription factor is a converging point of multiple
signal transduction pathways in many cells. We have previously demonstrated that …