Fenofibrate for COVID-19 and related complications as an approach to improve treatment outcomes: the missed key for Holy Grail
SS Alkhayyat, HM Al-Kuraishy, AI Al-Gareeb… - Inflammation …, 2022 - Springer
Introduction Fenofibrate is an agonist of peroxisome proliferator activated receptor alpha
(PPAR-α), that possesses anti-inflammatory, antioxidant, and anti-thrombotic properties …
(PPAR-α), that possesses anti-inflammatory, antioxidant, and anti-thrombotic properties …
The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused
a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to …
a significant number of fatalities and worldwide disruption. To identify drugs to repurpose to …
[HTML][HTML] Fenofibrate as a COVID-19 modifying drug: laboratory success versus real-world reality
It is of interest to note the benefits of statin therapy on mortality in hospitalised COVID-19
patients in the meta-analysis of retrospective observational studies by Kollias and …
patients in the meta-analysis of retrospective observational studies by Kollias and …
Efficacy and safety of metabolic interventions for the treatment of severe COVID-19: in vitro, observational, and non-randomized open-label interventional study
A Ehrlich, K Ioannidis, M Nasar, IA Alkian, Y Daskal… - Elife, 2023 - elifesciences.org
Background: Viral infection is associated with a significant rewire of the host metabolic
pathways, presenting attractive metabolic targets for intervention. Methods: We chart the …
pathways, presenting attractive metabolic targets for intervention. Methods: We chart the …
A randomized clinical trial of lipid metabolism modulation with fenofibrate for acute coronavirus disease 2019
JA Chirinos, P Lopez-Jaramillo… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cytotoxicity may involve
inhibition of peroxisome proliferator-activated receptor alpha. Fenofibrate activates …
inhibition of peroxisome proliferator-activated receptor alpha. Fenofibrate activates …
Role of pirfenidone in TGF-β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection: a theoretical …
SH Hamidi, S Kadamboor Veethil, SH Hamidi - Pharmacological Reports, 2021 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
pulmonary injury or multiple-organ injury by various pathological pathways. Transforming …
pulmonary injury or multiple-organ injury by various pathological pathways. Transforming …
[HTML][HTML] Molecular basis of quercetin as a plausible common denominator of macrophage-cholesterol-fenofibrate dependent potential COVID-19 treatment axis
The world's largest randomized control trial against COVID-19 using remdesivir,
hydroxychloroquine, lopinavir and interferon-β1a appeared to have little or no effect on …
hydroxychloroquine, lopinavir and interferon-β1a appeared to have little or no effect on …
[HTML][HTML] Fluvoxamine: a review of its mechanism of action and its role in COVID-19
Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake
inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized …
inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized …
Fluvoxamine in nonhospitalized patients with acute COVID-19 infection and the lack of efficacy in reducing rates of hospitalization, mechanical ventilation, and …
S Bhuta, W Khokher, N Kesireddy… - American journal of …, 2022 - journals.lww.com
Background: Recent clinical trials have investigated the use of fluvoxamine in preventing
clinical deterioration in nonhospitalized patients with acute COVID-19 infection via …
clinical deterioration in nonhospitalized patients with acute COVID-19 infection via …
Potential role of antioxidant and anti-inflammatory therapies to prevent severe SARS-Cov-2 complications
AM Fratta Pasini, C Stranieri, L Cominacini, C Mozzini - Antioxidants, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel severe acute
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …