Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons

XJ Zeng, SP Yu, L Zhang, L Wei - Experimental cell research, 2010 - Elsevier
The adipocytokine apelin and its G protein-coupled APJ receptor were initially isolated from
a bovine stomach and have been detected in the brain and cardiovascular system. Recent …

Apelin-13 protects the brain against ischemic reperfusion injury and cerebral edema in a transient model of focal cerebral ischemia

M Khaksari, N Aboutaleb, F Nasirinezhad… - Journal of Molecular …, 2012 - Springer
The adipocytokine apelin is a peptide that was isolated from a bovine stomach for the first
time. This peptide and its receptor are abundantly expressed in the nervous and …

Apelin protects myocardial injury induced by isoproterenol in rats

YX Jia, CS Pan, J Zhang, B Geng, J Zhao, H Gerns… - Regulatory peptides, 2006 - Elsevier
We aimed to explore the change in level of apelin and its receptor APJ during myocardial
injury and the therapeutic effects of apelin in myocardial injury. Rat myocardial injury was …

Apelin-13 attenuates traumatic brain injury-induced damage by suppressing autophagy

HJ Bao, L Zhang, WC Han, DK Dai - Neurochemical research, 2015 - Springer
The adipocytokine apelin is a peptide, Apelin and its receptor are abundantly expressed in
the nervous and cardiovascular systems. Previous studies had found apelin-13 reduces …

Apelin protects heart against ischemia/reperfusion injury in rat

XJ Zeng, LK Zhang, HX Wang, LQ Lu, LQ Ma, CS Tang - Peptides, 2009 - Elsevier
Apelin, the endogenous ligand of the G protein-coupled APJ receptor, is a peptide mediator
with emerging regulatory actions in the heart. We aimed to determine whether the …

Neuroprotection of apelin and its signaling pathway

B Cheng, J Chen, B Bai, Q Xin - Peptides, 2012 - Elsevier
Apelin was initially isolated from bovine stomach and is an endogenous neuropeptide. It is a
native ligand of the apelin receptor (APJ). Some research has found that apelin peptides …

The neuroprotective effect of apelin-13 in a mouse model of intracerebral hemorrhage

H Bao, X Yang, YX Huang, H Qiu, G Huang, H Xiao… - Neuroscience …, 2016 - Elsevier
Adipocytokine apelin-13 is a peptide which could reportedly protect the brain against
ischemic reperfusion injury and traumatic brain injury (TBI). Whether apelin-13 has any roles …

Apelin-13 and apelin-36 exhibit direct cardioprotective activity against ischemiareperfusion injury

JC Simpkin, DM Yellon, SM Davidson, SY Lim… - Basic research in …, 2007 - Springer
Protection against myocardial ischemia-reperfusion (I/R) injury involves activation of
phosphatidylinositol-3-OH kinase (PI3K)-Akt/protein kinase B and p44/42 mitogen-activated …

Apelin reduces myocardial reperfusion injury independently of PI3K/Akt and P70S6 kinase

MJ Kleinz, GF Baxter - Regulatory peptides, 2008 - Elsevier
Apelin, the endogenous ligand of the G protein-coupled APJ receptor, is a peptide mediator
with emerging regulatory actions in the heart. The aim of the present studies was to explore …

Apelin suppresses apoptosis of human osteoblasts

H Xie, LQ Yuan, XH Luo, J Huang, RR Cui, LJ Guo… - Apoptosis, 2007 - Springer
Objectives: Apelin is a recently discovered peptide that is the endogenous ligand for the
orphan G-protein-coupled receptor APJ. Adipocytes can express and secrete apelin …