Abstract Sphingosine kinase 1 (Sphk1), a key enzyme responsible for phosphorylating
sphingosine into sphingosine1-phosphate (S1P), plays an important role in mediating post …

Sphingosine kinases (Sphks) are the rate-limiting kinases in the generation of sphingosine-
1-phosphate, which is a well-established intracellular pro-survival lipid mediator. Sphk2 has …

Background Microglial activation is one of the causative factors of neuroinflammation in
cerebral ischemia/reperfusion (IR). Sphingosine kinase 1 (Sphk1), a key enzyme …

The pathogenesis of inflammation in the central nervous system (CNS), which contributes to
numerous neurodegenerative diseases and results in encephalopathy and …

Background The pathological process of traumatic spinal cord injury (SCI) involves
excessive activation of microglia leading to the overproduction of proinflammatory cytokines …

Microglial hyperactivation mediated by sphingosine kinase 1/sphingosine‐1‐phosphate
(SphK1/S1P) signalling and the consequent inflammatory mediator production serve as the …

Background The pathogenic roles of receptor-mediated sphingosine 1-phosphate (S1P)
signaling in cerebral ischemia have been evidenced mainly through the efficacy of FTY720 …

Microglial activation has been implicated as one of the causative factors for
neuroinflammation in various neurodegenerative diseases. The sphingolipid metabolic …

Stroke is associated with high morbidity and mortality, and much remains unknown about
the injury-related mechanisms that occur following reperfusion. This study aimed to explore …

Sphingosine 1-phosphate (S1P) is involved in a variety of cellular responses including
microglial activation and polarization. However, the impacts of S1P on ischemia-induced …