Dopamine is critical for many processes that drive learning and memory, including motivation, prediction error, incentive salience, memory consolidation, and response output …
It is a joyous relief when an event we dread fails to materialize. In fear extinction, the appetitive nature of an omitted aversive event is not a mere epiphenomenon but drives the …
RA Wise - Nature reviews neuroscience, 2004 - nature.com
The hypothesis that dopamine is important for reward has been proposed in a number of forms, each of which has been challenged. Normally, rewarding stimuli such as food, water …
S Papalini, T Beckers, B Vervliet - Translational psychiatry, 2020 - nature.com
Dopamine, one of the main neurotransmitters in the mammalian brain, has been implicated in the coding of prediction errors that govern reward learning as well as fear extinction …
The ability to extinguish fear memories when threats are no longer present is critical for adaptive behavior. Fear extinction represents a new learning process that eventually leads …
Recent advances in the cognitive neuroscience of motivation and learning have demonstrated a critical role for midbrain dopamine and its targets in reward prediction …
R Luo, A Uematsu, A Weitemier, L Aquili… - Nature …, 2018 - nature.com
Overcoming aversive emotional memories requires neural systems that detect when fear responses are no longer appropriate so that they can be extinguished. The midbrain ventral …
Extinction of behavior enables adaptation to a changing world and is crucial for recovery from disorders such as phobias and drug addiction. However, the brain mechanisms …