Read alignment is a time-consuming step in genome sequencing analysis. The most widely
used software for read alignment, BWA-MEM, and the recently published faster version BWA …

Sequence alignment pipelines for human genomes are an emerging workload that will
dominate in the precision medicine field. BWA-MEM2 is a tool widely used in the scientific …

When computing alignments of DNA sequences to a large genome, a key element in
achieving high processing throughput is to prioritize locations in the genome where high …

Genome analysis is a critical tool in medical and bioscience research, clinical diagnostics
and treatment, and disease control and prevention. Seed and extension-based alignment is …

Genomics can transform health-care through precision medicine. Plummeting sequencing
costs would soon make genome testing affordable to the masses. Compute efficiency …

Genome sequence alignment is the core of many biological applications. The advancement
of sequencing technologies produces a tremendous amount of data, making sequence …

As advances in Next-Generation Sequencing have made genome sequence data
generation faster and cheaper, the acceleration of genome sequence mapping to the …

Precision Medicine will rely on frequent genomic analysis, especially for patients
undergoing cancer treatments or suffering from rare diseases. Sequence alignment is …

Genomics is the key to enable the personal customization of medical care. How to fast and
energy-efficiently analyze the huge amounts of genomic sequence data generated by next …

Motivation Read alignment is central to many aspects of modern genomics. Most aligners
use heuristics to accelerate processing, but these heuristics can fail to find the optimal …