The tumor suppressor gene p53 and its family members p63/p73 are critical determinants of
tumorigenesis. ΔNp63 is a splice variant of p63, which lacks the N-terminal transactivation …

This study examined immunohistochemical expression of ΔNp63, a keratinocyte stem cell
marker, in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) and then to …

The tumor suppressor p53 and its oncogenic sibling p63 (ΔNp63) direct opposing fates in
tumor development. These paralog proteins are transcription factors that elicit their tumor …

As a member of tumor suppressor p53 family, p63, a gene encoding versatile protein variant,
has been documented to correlate with cancer formation and progression, though it is rarely …

Unlike its family member p53, TP63 is rarely mutated in human cancer. However, ΔNp63α
protein levels are often elevated in tumors of epithelial origin, such as squamous cell …

ΔNp63 (henceforth simply p40) is a squamous/basal-type biomarker corresponding to
nontransactivating (non-TA) isoforms of p63 gene. Its prospective relevance as driver …

Mutation of the p53 gene is a common event in human cancer. Interestingly, p53 mutation is
uncommon in nasopharyngeal carcinoma (NPC). The ΔNp63 has been postulated to have a …

Undifferentiated nasopharyngeal carcinoma (NPC) is an epithelial malignancy that is
consistently associated with Epstein-Barr virus (EBV) but which very rarely has p53 gene …

The p63 transcription factor has a pivotal role in epithelial morphogenesis. Multiple
transcripts of the TP63 gene are generated because of alternative promoter usage and …

The P53 homolog p63 encodes multiple proteins with transactivating, apoptosis-inducing,
and oncogenic activities. We showed that p63 is amplified and that ΔNp63 isotypes are …