Epithelial-mesenchymal transition (EMT) is a physiological process that plays important
roles in tumor metastasis," stemness," and drug resistance. EMT is typically characterized by …

TP63 is a member of the TP53 gene family that encodes for up to ten different TA and ΔN
isoforms through alternative promoter usage and alternative splicing. Besides being a …

Background ΔNp63 is a master transcriptional regulator playing critical roles in epidermal
development and other cellular processes. Recent studies suggest that ΔNp63 functions as …

The transcription factor p63 belongs to the p53 family and is a key regulator in epithelial
commitment and development. Mutations in p63 give rise to several epithelial related …

Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to current chemotherapy
regimens, in part due to alterations in the p53 tumor suppressor pathway. p53 homolog p63 …

The phenotypes of the p63 mutant mice are complex and diverse. The p63-/-mice develop
severe defects in morphogenesis of ectodermal appendages, and p63+/-mice are tumor …

Cell identity signals influence the invasive capability of tumor cells, as demonstrated by the
selection for programs of epithelial-to-mesenchymal transition (EMT) during malignant …

In stratified epithelial and glandular tissues, homeostasis relies on the self-renewing
capacity of stem cells, which are within the basal layer. The p53 family member p63 is an …

Levels of the N-terminally truncated isoform of p63 (ΔN p63), well documented to play a
pivotal role in basal epidermal gene expression and epithelial maintenance, need to be …

Tumor protein (TP)-p53 family members (TP63, TP63 and TP73) are guardians of the
genome and key players in orchestrating the cellular response to cisplatin treatment …