[HTML][HTML] Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients

C Wang, J Xie, L Zhao, X Fei, H Zhang, Y Tan, X Nie… - …, 2020 - thelancet.com
Background The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection
could lead to a series of clinical symptoms and severe illnesses, including acute respiratory …

Clinical pathology of critical patient with novel coronavirus pneumonia (COVID-19)

W Luo, H Yu, J Gou, X Li, Y Sun, J Li, L Liu - 2020 - preprints.org
Background Critical patients with novel coronavirus pneumonia (COVID-19) have worse
outcome and high mortality. However, the histopathology of critical patient with COVID-19 …

[HTML][HTML] The pulmonary pathology of COVID-19

H Bösmüller, M Matter, F Fend, A Tzankov - Virchows Archiv, 2021 - Springer
The lung is the main affected organ in severe coronavirus disease 2019 (COVID-19) caused
by the novel coronavirus SARS-CoV-2, and lung damage is the leading cause of death in …

[HTML][HTML] SARS-CoV-2 activates lung epithelial cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients

H Chen, W Liu, Y Wang, D Liu, L Zhao, J Yu - EBioMedicine, 2021 - thelancet.com
Abstract Background The outbreak of Coronavirus disease 2019 (COVID-19) caused by
SARS-CoV-2 infection has become a global health emergency. We aim to decipher SARS …

Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases

Q Liu, Y Shi, J Cai, Y Duan, R Wang… - National science …, 2020 - academic.oup.com
Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents
should provide insights into the disease characteristics and facilitate the development of …

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

Y Xiong, Y Liu, L Cao, D Wang, M Guo… - Emerging microbes & …, 2020 - Taylor & Francis
Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak
has caused devastating mortality and posed a great threat to public health. However, efforts …

[HTML][HTML] SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation

S Li, Y Zhang, Z Guan, H Li, M Ye, X Chen… - Signal transduction and …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to
respiratory illness and multi-organ failure in critically ill patients. Although the virus-induced …

[HTML][HTML] Aveolar macrophage activation and cytokine storm in the pathogenesis of severe COVID-19

C Wang, J Xie, L Zhao, X Fei, H Zhang, Y Tan, L Zhou… - 2020 - europepmc.org
Abstract The coronavirus disease-19 (COVID-19) caused by SARS-CoV-2 infection can lead
to a series of clinical settings from non-symptomatic viral carriers/spreaders to severe illness …

[HTML][HTML] COVID-19 lung pathogenesis in SARS-CoV-2 autopsy cases

S Valdebenito, S Bessis, D Annane… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health
issue. COVID-19 is considered an airway/multi-systemic disease, and demise has been …

[HTML][HTML] Tracking the time course of pathological patterns of lung injury in severe COVID-19

T Mauad, AN Duarte-Neto, LFF da Silva… - Respiratory …, 2021 - Springer
Background Pulmonary involvement in COVID-19 is characterized pathologically by diffuse
alveolar damage (DAD) and thrombosis, leading to the clinical picture of Acute Respiratory …