Background COVID19 is caused by the SARS-CoV-2 virus and has been associated with
severe inflammation leading to organ dysfunction and mortality. Our aim was to profile the …

SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic.
Severe complications are observed only in a small proportion of infected patients but the …

Mechanisms of neutrophil involvement in severe coronavirus disease 2019 (COVID-19)
remain incompletely understood. Here, we collect longitudinal blood samples from 306 …

Whilst the majority of individuals infected with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, experience mild to …

At homeostasis the vast majority of neutrophils in the circulation expresses CD16 and
CD62L within a narrow expression range, but this quickly changes in disease. Little is …

Increased production of inflammatory cytokines and myeloid-derived suppressor cells
occurs in patients with coronavirus disease 2019. These inversely correlated with perforin …

BACKGROUND Elevated levels of inflammatory cytokines have been associated with poor
outcomes among COVID-19 patients. It is unknown, however, how these levels compare …

The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is a public health emergency of international concern. The …

The objective of the present study was to identify biological signatures of severe coronavirus
disease 2019 (COVID-19) predictive of admission in the intensive care unit (ICU). Over 170 …

COVID-19 pathogenesis is associated with an exaggerated immune response. However, the
specific cellular mediators and inflammatory components driving diverse clinical disease …