Context.—Previous studies of BRCA1 mutation prevalence have been based on high-risk
groups, yielding estimates that do not reflect the experience of the general population of US …

An account of familial aggregation in breast/ovarian cancer has become possible with the
identification of BRCA1 germ-line mutations. We evaluated, for 249 individuals registered …

Context.—Studies of high-risk families with multiple early-onset cases of breast cancer have
been useful for assessing the type and spectrum of germline mutations on the BRCA1 gene …

Genetic epidemiological evidence suggests that mutations in BRCA1 may be responsible for
approximately one half of early onset familial breast cancer and the majority of familial …

Background Inherited mutations in the BRCA1 gene confer a high risk of breast and ovarian
cancer in some families. To determine the contribution of BRCA1 mutations to ovarian …

Background To define the incidence of BRCA1 mutations among patients seen in clinics that
evaluate the risk of breast cancer, we analyzed DNA samples from women seen in this …

BACKGROUND There is a clear and growing need for data regarding BRCA1 and BRCA2
mutation frequencies among breast carcinoma cases not specifically ascertained on the …

To the Editor: Genetic susceptibility has been estimated to contribute to 5%-10% of all breast
cancer cases but to-25% of cases diagnosed before age 30 years (Kelsey and Gam-mon …

Abstract BACKGROUND: Approximately 2.0%-2.5% of Ashkenazi Jewish women carry one
of three founding mutations in the BRCA1 and BRCA2 genes, and each mutation is …

Most multiple case families of young onset breast cancer and ovarian cancer are thought to
be due to highly penetrant mutations in the predisposing genes BRCA1 and BRCA2 …