Molecular mechanism of the N501Y mutation for enhanced binding between SARS-CoV-2's spike protein and human ACE2 receptor

B Luan, H Wang, T Huynh - BioRxiv, 2021 - biorxiv.org
Abstract Coronavirus disease 2019 (COVID-19) has been an ongoing global pandemic for
over a year. Recently, an emergent SARS-CoV-2 variant (B. 1.1. 7) with an unusually large …

[HTML][HTML] Impact of the double mutants on spike protein of SARS-CoV-2 B. 1.617 lineage on the human ACE2 receptor binding: A structural insight

MI Khan, MH Baig, T Mondal, M Alorabi, T Sharma… - Viruses, 2021 - mdpi.com
The recent emergence of novel SARS-CoV-2 variants has threatened the efforts to contain
the COVID-19 pandemic. The emergence of these “variants of concern” has increased …

Mechanistic insights into the effects of key mutations on SARS-CoV-2 RBD–ACE2 binding

A Aggarwal, S Naskar, N Maroli, B Gorai… - Physical Chemistry …, 2021 - pubs.rsc.org
Some recent SARS-CoV-2 variants appear to have increased transmissibility compared to
the original strain. An underlying mechanism could be the improved ability of the variants to …

[HTML][HTML] Interactions of angiotensin-converting enzyme-2 (ACE2) and SARS-CoV-2 spike receptor-binding domain (RBD): a structural perspective

S Borkotoky, D Dey, Z Hazarika - Molecular biology reports, 2023 - Springer
Abstract Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has
caused millions of infections and deaths worldwide since its discovery in late 2019 in …

Mutation N501Y in RBD of Spike Protein Strengthens the Interaction between COVID-19 and its Receptor ACE2

F Tian, B Tong, L Sun, S Shi, B Zheng, Z Wang, X Dong… - BioRxiv, 2021 - biorxiv.org
ABSTRACT SARS-CoV-2 is spreading around the world for the past year. Enormous efforts
have been taken to understand its mechanism of transmission. It is well established now that …

[HTML][HTML] Mutations in the SARS-CoV-2 spike protein modulate the virus affinity to the human ACE2 receptor, an in silico analysis

JT Ortega, FH Pujol, B Jastrzebska, HR Rangel - EXCLI journal, 2021 - ncbi.nlm.nih.gov
The increasing number of SARS-CoV-2 variants associated with highly transmissible
phenotypes is a health-public concern in the current pandemic scenario. Herein, we …

Enhanced binding of SARS-CoV-2 spike protein to receptor by distal polybasic cleavage sites

B Qiao, M Olvera de la Cruz - ACS nano, 2020 - ACS Publications
The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein plays a crucial role in
binding the human cell receptor ACE2 that is required for viral entry. Many studies have …

[HTML][HTML] Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2

A Singh, G Steinkellner, K Köchl, K Gruber… - Scientific reports, 2021 - nature.com
Since the worldwide outbreak of the infectious disease COVID-19, several studies have
been published to understand the structural mechanism of the novel coronavirus SARS-CoV …

Critical interactions between the SARS-CoV-2 spike glycoprotein and the human ACE2 receptor

E Taka, SZ Yilmaz, M Golcuk, C Kilinc… - The Journal of …, 2021 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects human cells by
binding its spike (S) glycoproteins to angiotensin-converting enzyme 2 (ACE2) receptors …

Machine learning reveals the critical interactions for SARS-CoV-2 spike protein binding to ACE2

A Pavlova, Z Zhang, A Acharya, DL Lynch… - The journal of …, 2021 - ACS Publications
SARS-CoV and SARS-CoV-2 bind to the human ACE2 receptor in practically identical
conformations, although several residues of the receptor-binding domain (RBD) differ …