Summary The HIV-1-envelope glycoprotein (Env) is the main target of antigen design for
antibody-based prophylactic vaccines. The generation of broadly neutralizing antibodies …

Despite recent progress in engineering native trimeric HIV-1 envelope glycoprotein (Env)
mimics as vaccine candidates, Env trimers often induce vaccine-matched neutralizing …

Major neutralizing antibody immune evasion strategies of the HIV-1 envelope glycoprotein
(Env) trimer include conformational and structural instability. Stabilized soluble trimers such …

Stabilized HIV-1 envelope glycoproteins (Env) that resemble the native Env are utilized in
vaccination strategies aimed at inducing broadly neutralizing antibodies (bNAbs). To limit …

The trimeric envelope glycoprotein spike (Env) of HIV-1 is the target of vaccine development
to elicit broadly neutralizing antibodies (bnAbs). Env trimer instability and heterogeneity in …

A successful HIV-1 vaccine will likely need to elicit broadly neutralizing antibodies (bNAbs)
that target the envelope glycoprotein (Env) spike on the virus. Native-like recombinant Env …

The identification of multiple broadly neutralizing antibodies (bNAbs) against the HIV-1
envelope glycoprotein (Env) trimer has facilitated its structural characterization and guided …

Structure determination of the HIV‐1 envelope glycoprotein (Env) presented a number of
challenges, but several high‐resolution structures have now become available. In 2013 …

The production of native-like recombinant versions of the HIV-1 envelope glycoprotein (Env)
trimer requires overcoming the natural flexibility and instability of the complex. The …

An effective HIV-1 vaccine probably will need to be able to induce broadly neutralizing HIV-1
antibodies (bNAbs) in order to be efficacious. The many bNAbs that have been isolated from …