CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte
activation during the adaptive immune response. Somatic mutations in CARD11 are …

CARD11 is a lymphocyte-specific scaffold molecule required for proper activation of B-and T-
cells in response to antigen. Germline gain-of-function (GOF) mutations in the CARD11 …

Caspase recruitment domain protein 9 (CARD9) forms essential signaling complexes in the
innate immune system that integrate cues from C-type lectin receptors and specific …

CARD9 is a caspase recruitment domain-containing signaling protein that plays a critical
role in innate and adaptive immunity. It has been widely demonstrated that CARD9 adaptor …

CARD11-associated diseases are monogenic inborn errors of immunity involving
immunodeficiency, predisposition to malignancy and immune dysregulation such as …

Background: Inherited CARD9 deficiency constitutes a primary immunodeficiency
predisposing uniquely to chronic and invasive fungal infections. Certain mutations are …

The adaptor protein CARD9 is in charge of mediating signals from PRRs of myeloid cells to
downstream transcription factor NF-κB. CARD9 plays an indispensable role in innate …

Background Caspase activation and recruitment domain 11 (CARD11) encodes a scaffold
protein in lymphocytes that links antigen receptor engagement with downstream signaling to …

CARD9 is a signaling adaptor protein that is involved in the transduction of signals from a
variety of innate pattern recognition receptors, including the C-type lectin receptors and …

The CARD11 signaling scaffold transmits signaling between antigen receptors on B and T
lymphocytes and the transcription factor NF-κB during the adaptive immune response …