[HTML][HTML] CRISPR-Cas systems for genome editing, regulation and targeting
JD Sander, JK Joung - Nature biotechnology, 2014 - ncbi.nlm.nih.gov
Targeted genome editing using engineered nucleases has rapidly transformed from a niche
technology to a mainstream method used by many biological researchers. This widespread …
technology to a mainstream method used by many biological researchers. This widespread …
CRISPR-Cas systems for editing, regulating and targeting genomes
JD Sander, JK Joung - Nature biotechnology, 2014 - nature.com
Targeted genome editing using engineered nucleases has rapidly gone from being a niche
technology to a mainstream method used by many biological researchers. This widespread …
technology to a mainstream method used by many biological researchers. This widespread …
Beyond native Cas9: manipulating genomic information and function
Clustered regularly interspaced short palindromic repeats (CRISPR)-mediated manipulation
of genomic information is becoming more versatile by combining nuclease-deficient …
of genomic information is becoming more versatile by combining nuclease-deficient …
Development of CRISPR-Cas systems for genome editing and beyond
F Zhang - Quarterly Reviews of Biophysics, 2019 - cambridge.org
The development of clustered regularly interspaced short-palindromic repeat (CRISPR)-Cas
systems for genome editing has transformed the way life science research is conducted and …
systems for genome editing has transformed the way life science research is conducted and …
Wide horizons of CRISPR-Cas-derived technologies for basic biology, agriculture, and medicine
The discovery and subsequent repurposing of the CRISPR (clustered regularly interspaced
short palindromic repeats) and Cas proteins (CRISPR-associated proteins) has …
short palindromic repeats) and Cas proteins (CRISPR-associated proteins) has …
CRISPR-based technologies for the manipulation of eukaryotic genomes
The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of
advances in the life sciences that have grown from the ability to edit genomes within living …
advances in the life sciences that have grown from the ability to edit genomes within living …
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
Y Fu, JD Sander, D Reyon, VM Cascio… - Nature biotechnology, 2014 - nature.com
Clustered, regularly interspaced, short palindromic repeat (CRISPR) RNA-guided nucleases
(RGNs) are highly efficient genome editing tools,,. CRISPR-associated 9 (Cas9) RGNs are …
(RGNs) are highly efficient genome editing tools,,. CRISPR-associated 9 (Cas9) RGNs are …
The new frontier of genome engineering with CRISPR-Cas9
JA Doudna, E Charpentier - Science, 2014 - science.org
Background Technologies for making and manipulating DNA have enabled advances in
biology ever since the discovery of the DNA double helix. But introducing site-specific …
biology ever since the discovery of the DNA double helix. But introducing site-specific …
CRISPR-Cas guides the future of genetic engineering
The diversity, modularity, and efficacy of CRISPR-Cas systems are driving a
biotechnological revolution. RNA-guided Cas enzymes have been adopted as tools to …
biotechnological revolution. RNA-guided Cas enzymes have been adopted as tools to …
Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing
Compact and versatile CRISPR-Cas systems will enable genome engineering applications
through high-efficiency delivery in a wide variety of contexts. Here, we create an efficient …
through high-efficiency delivery in a wide variety of contexts. Here, we create an efficient …