Primary severe acute respiratory syndrome coronavirus infection limits replication but not lung inflammation upon homologous rechallenge
C Clay, N Donart, N Fomukong, JB Knight… - Journal of …, 2012 - Am Soc Microbiol
Our knowledge regarding immune-protective and immunopathogenic events in severe acute
respiratory syndrome coronavirus (SARS-CoV) infection is limited, and little is known about …
respiratory syndrome coronavirus (SARS-CoV) infection is limited, and little is known about …
Severe acute respiratory syndrome and the innate immune responses: modulation of effector cell function without productive infection
CTK Tseng, LA Perrone, H Zhu, S Makino… - The Journal of …, 2005 - journals.aai.org
Severe acute respiratory syndrome (SARS) caused by a novel human coronavirus (CoV),
designated SARS-CoV, is a highly contagious respiratory disease with the lungs as a major …
designated SARS-CoV, is a highly contagious respiratory disease with the lungs as a major …
T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice
J Zhao, J Zhao, S Perlman - Journal of virology, 2010 - Am Soc Microbiol
ABSTRACT A dysregulated innate immune response and exuberant cytokine/chemokine
expression are believed to be critical factors in the pathogenesis of severe acute respiratory …
expression are believed to be critical factors in the pathogenesis of severe acute respiratory …
[HTML][HTML] Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques
L Liu, Q Wei, K Nishiura, J Peng, H Wang, C Midkiff… - Mucosal …, 2016 - Elsevier
Innate immune responses have a critical role in the control of early virus replication and
dissemination. It remains unknown, however, how severe acute respiratory syndrome …
dissemination. It remains unknown, however, how severe acute respiratory syndrome …
Mucosal and systemic responses to severe acute respiratory syndrome coronavirus 2 vaccination determined by severity of primary infection
With much of the world infected with or vaccinated against severe acute respiratory
syndrome coronavirus 2 (commonly abbreviated SARS-CoV-2; abbreviated here SARS2) …
syndrome coronavirus 2 (commonly abbreviated SARS-CoV-2; abbreviated here SARS2) …
[HTML][HTML] A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection
LFP Ng, ML Hibberd, EE Ooi, KF Tang, SY Neo… - BMC infectious …, 2004 - Springer
Background The molecular basis of severe acute respiratory syndrome (SARS) coronavirus
(CoV) induced pathology is still largely unclear. Many SARS patients suffer respiratory …
(CoV) induced pathology is still largely unclear. Many SARS patients suffer respiratory …
Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young …
N Nagata, N Iwata, H Hasegawa, S Fukushi… - The American journal of …, 2008 - Elsevier
Advanced age is a risk factor of severe acute respiratory syndrome (SARS) in humans. To
understand its pathogenesis, we developed an animal model using BALB/c mice and the …
understand its pathogenesis, we developed an animal model using BALB/c mice and the …
Escape from human monoclonal antibody neutralization affects in vitro and in vivo fitness of severe acute respiratory syndrome coronavirus
B Rockx, E Donaldson, M Frieman… - The Journal of …, 2010 - academic.oup.com
Background. Severe acute respiratory syndrome (SARS) emerged as a human disease in
2002. Detailed phylogenetic analysis and epidemiologic studies have suggested that the …
2002. Detailed phylogenetic analysis and epidemiologic studies have suggested that the …
Severe acute respiratory syndrome (SARS) coronavirus-induced lung epithelial cytokines exacerbate SARS pathogenesis by modulating intrinsic functions of …
T Yoshikawa, T Hill, K Li, CJ Peters… - Journal of virology, 2009 - Am Soc Microbiol
Severe acute respiratory syndrome (SARS), which is caused by a novel coronavirus (CoV),
is a highly communicable disease with the lungs as the major pathological target. Although …
is a highly communicable disease with the lungs as the major pathological target. Although …
[HTML][HTML] SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism
MB Frieman, J Chen, TE Morrison, A Whitmore… - PLoS …, 2010 - journals.plos.org
Severe acute respiratory syndrome coronavirus (SARS-CoV) infection often caused severe
end stage lung disease and organizing phase diffuse alveolar damage, especially in the …
end stage lung disease and organizing phase diffuse alveolar damage, especially in the …