Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome

DD Krueger, EK Osterweil, SP Chen… - Proceedings of the …, 2011 - National Acad Sciences
Among the hallmark phenotypes reported in individuals with fragile X syndrome (FXS) are
deficits in attentional function, inhibitory control, and cognitive flexibility, a set of cognitive …

Neuroanatomical, molecular genetic, and behavioral correlates of fragile X syndrome

SD Koukoui, A Chaudhuri - Brain research reviews, 2007 - Elsevier
Fragile X syndrome (FXS) is a leading cause of inherited mental retardation. In the vast
majority of cases, this X-linked disorder is due to a CGG expansion in the 5′ untranslated …

Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome

SM Till, LS Wijetunge, VG Seidel… - Human molecular …, 2012 - academic.oup.com
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and
results from the loss of the fragile X mental retardation protein (FMRP). Many fragile X …

Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins

CM Spencer, E Serysheva… - Human molecular …, 2006 - academic.oup.com
Individuals affected by Fragile X syndrome (FXS) experience cognitive impairment,
hyperactivity, attention deficits, social anxiety and autistic-like behaviors. FXS results from …

Cellular distribution of the fragile X mental retardation protein in the mouse brain

DAR Zorio, CM Jackson, Y Liu… - Journal of …, 2017 - Wiley Online Library
The fragile X mental retardation protein (FMRP) plays an important role in normal brain
development. Absence of FMRP results in abnormal neuronal morphologies in a selected …

Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us

AR Santos, AK Kanellopoulos, C Bagni - Learning & memory, 2014 - learnmem.cshlp.org
The Fragile X syndrome (FXS) is the most frequent form of inherited mental disability and is
considered a monogenic cause of autism spectrum disorder. FXS is caused by a triplet …

Anatomical phenotyping in a mouse model of fragile X syndrome with magnetic resonance imaging

J Ellegood, LK Pacey, DR Hampson, JP Lerch… - Neuroimage, 2010 - Elsevier
Fragile X Syndrome (FXS) is the most common single gene cause of inherited mental
impairment, and cognitive deficits can range from simple learning disabilities to mental …

Fragile X mental retardation protein in learning-related synaptic plasticity

V Mercaldo, G Descalzi, M Zhuo - Molecules and cells, 2009 - Springer
Fragile X syndrome (FXS) is caused by a lack of the fragile X mental retardation protein
(FMRP) due to silencing of the Fmr1 gene. As an RNA binding protein, FMRP is thought to …

Gene, brain, and behavior relationships in fragile X syndrome: evidence from neuroimaging studies

AA Lightbody, AL Reiss - Developmental disabilities research …, 2009 - Wiley Online Library
Fragile X syndrome (FraX) remains the most common inherited cause of intellectual
disability and provides a valuable model for studying gene‐brain‐behavior relationships …

Age-dependent cognitive changes in carriers of the fragile X syndrome

KM Cornish, L Li, CS Kogan, S Jacquemont, J Turk… - cortex, 2008 - Elsevier
Fragile X syndrome is a neurodevelopmental disorder that is caused by the silencing of a
single gene on the X chromosome, the fragile X mental retardation 1 (FMR1) gene. Affected …