Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism
Background Tip60 is a key histone acetyltransferase (HAT) enzyme that plays a central role
in diverse biological processes critical for general cell function; however, the chromatin …
in diverse biological processes critical for general cell function; however, the chromatin …
The Cloning and Characterization of the Histone Acetyltransferase Human Homolog Dmel\TIP60 in Drosophila melanogaster: Dmel\TIP60 Is Essential for …
Chromatin packaging directly influences gene programming as it permits only certain
portions of the genome to be activated in any given developmental stage, cell, and tissue …
portions of the genome to be activated in any given developmental stage, cell, and tissue …
Disruption of Tip60 HAT mediated neural histone acetylation homeostasis is an early common event in neurodegenerative diseases
Epigenetic dysregulation is a common mechanism shared by molecularly and clinically
heterogenous neurodegenerative diseases (NDs). Histone acetylation homeostasis …
heterogenous neurodegenerative diseases (NDs). Histone acetylation homeostasis …
Tip off the HAT– Epigenetic control of learning and memory by Drosophila Tip60
Disruption of epigenetic gene control mechanisms involving histone acetylation in the brain
causes cognitive impairment, a debilitating hallmark of most neurodegenerative disorders …
causes cognitive impairment, a debilitating hallmark of most neurodegenerative disorders …
Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60
C Schirling, C Heseding, F Heise, D Kesper, A Klebes… - Chromosoma, 2010 - Springer
The MYST histone acetyltransferase (HAT) dTip60 is part of a multimeric protein complex
that unites both HAT and chromatin remodeling activities. Here, we sought to gain insight …
that unites both HAT and chromatin remodeling activities. Here, we sought to gain insight …
Tip60-mediated H2A. Z acetylation promotes neuronal fate specification and bivalent gene activation
Cell lineage specification is accomplished by a concerted action of chromatin remodeling
and tissue-specific transcription factors. However, the mechanisms that induce and maintain …
and tissue-specific transcription factors. However, the mechanisms that induce and maintain …
Tip60 HAT Activity Mediates APP Induced Lethality and Apoptotic Cell Death in the CNS of a Drosophila Alzheimer's Disease Model
SK Pirooznia, J Sarthi, AA Johnson, MS Toth, K Chiu… - 2012 - journals.plos.org
Histone acetylation of chromatin promotes dynamic transcriptional responses in neurons
that influence neuroplasticity critical for cognitive ability. It has been demonstrated that Tip60 …
that influence neuroplasticity critical for cognitive ability. It has been demonstrated that Tip60 …
dTip60 HAT Activity Controls Synaptic Bouton Expansion at the Drosophila Neuromuscular Junction
Background Histone acetylation of chromatin plays a key role in promoting the dynamic
transcriptional responses in neurons that influence the neuroplasticity linked to cognitive …
transcriptional responses in neurons that influence the neuroplasticity linked to cognitive …
Hdac6 regulates Tip60-p400 function in stem cells
In embryonic stem cells (ESCs), the Tip60 histone acetyltransferase activates genes
required for proliferation and silences genes that promote differentiation. Here we show that …
required for proliferation and silences genes that promote differentiation. Here we show that …
Epigenetic Control of Learning and Memory in Drosophila by Tip60 HAT Action
Disruption of epigenetic gene control mechanisms in the brain causes significant cognitive
impairment that is a debilitating hallmark of most neurodegenerative disorders, including …
impairment that is a debilitating hallmark of most neurodegenerative disorders, including …