Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) have crucial roles in
both physiological and pathological angiogenesis. The VEGF family consists of VEGF-A …

Angiogenesis, or formation of new blood capillaries from preexisting vessels, plays both
beneficial and damaging roles in the organism. It is a result of a complex balance of positive …

New blood vessel formation (angiogenesis) is fundamental to the process of tumor growth,
invasion, and metastatic dissemination. The vascular endothelial growth factor (VEGF) …

Angiogenesis, the formation of new blood vessels from pre-existing ones, plays a central
role in the process of tumor growth and metastasis. The proliferation of endothelium and …

Vascular endothelial growth factor (VEGF) represents a growth factor with important pro-
angiogenic activity, having a mitogenic and an anti-apoptotic effect on endothelial cells …

Abstract Learning Objectives After completing this course, the reader will be able to: Explain
the biology of angiogenesis. Identify the role of VEGF in normal and tumor angiogenesis …

Among the known angiogenic growth factors and cytokines implicated in the modulation of
normal and pathological angiogenesis, the VEGF family (VEGF-A, VEGF-B, VEGF-C, VEGF …

Angiogenesis is a process of development and of growth of new capillary blood vessels from
pre-existing vessels. When pathological, it contributes to the development of numerous …

Induction of angiogenesis represents one of the major hallmarks of cancer. The growth of
new vessels is crucial to provide malignant cells with an adequate supply of oxygen and …

The dependence of tumor growth on the development of a neovasculature is well-
established [1]. After a tumor grows beyond 100 mm to 200 mm in size, diffusion alone is no …