The relationship between pain severity and the extent of injury to a peripheral nerve remains
elusive. In this study, we compared the pain behavior resulting from partial (1/3–1/2 …

L5 and L6 spinal nerve ligation (SNL) in rats leads to behavioral signs of neuropathic pain
including mechanical allodynia. The purposes of this study were to investigate the role of the …

L5/L6 spinal nerve ligation (SNL) in rodents induces behavioral signs similar to the
symptoms of neuropathic pain in humans. L5/L6 SNL in rats has been well characterized so …

Rodent models of neuropathic pain are used to investigate the underlying mechanisms of
pain associated with damage to peripheral nerves and to evaluate the efficacy of novel …

An injury to a peripheral nerve in animals often leads to signs of neuropathic pain including
hyperalgesia to heat, cold and mechanical stimuli. The role of injured and intact nerve fibers …

Spinal nerve L5/L6 ligation (SNL) in rats has become the standard for mechanistic studies of
peripheral neuropathy and screening for novel analgesics. Conventional SNL in our hybrid …

Studies in experimental models and controlled patient trials indicate that opioids are
effective in managing neuropathic pain. However, side effects secondary to their central …

Using lumbar 5 (L5) dorsal root rhizotomy-bearing rats, we examined the extent to which L5
spinal nerve lesion (SNL)-induced mechanical hyperalgesia was governed by two …

Mechanical allodynia-and hyperalgesia-like behavior which develops in rats after L5 spinal
nerve lesion has been suggested to be due to ectopic activity in the lesioned afferent …

We studied the effect of unilateral ligation of two spinal nerves on behavioral pain responses
evoked by various types of cutaneous stimuli in the adult rat. Furthermore, we determined …