Lipid rafts are defined as detergent-resistant membrane microdomains of specific lipid and
protein composition. They are involved in many aspects of cell biology, including T-cell …

Lipid rafts are dynamic assemblies of proteins and lipids that harbour many receptors and
regulatory molecules and so act as a platform for signal transduction. They float freely within …

Lipid rafts are established as critical structures for a variety of cellular processes, including
immune cell activation. Beyond their importance for initial immune cell activation at the …

During the past decade, the lipid‐raft hypothesis has focused attention on the role of
membrane domains in controlling cellular functions. Among the best‐studied roles of lipid …

Experimental evidence indicates that the mammalian cell membrane is compartmentalized.
A structural feature that supports membrane segmentation implicates assemblies of selected …

Lipid rafts is a blanket term used to describe distinct areas in the plasma membrane rich in
certain lipids and proteins and which are thought to perform diverse functions. A large …

Engagement of immune receptors by antigen may lead to activation, cell proliferation,
differentiation and effector functions. It has recently been proposed that the initiation and …

The first appearance of lipid rafts, or lipid rafts-like structure, was occasionally observed by
cryo-electronic microscopy in 1980s as cavity, such as caveolae. However, the fully …

Background Lipid rafts are cholesterol and saturated lipid-rich, nanometer sized membrane
domains that are hypothesized to play an important role in compartmentalization and …

While the existence of cholesterol/sphingolipid (raft) membrane domains in the plasma
membrane is now supported by strong experimental evidence, the structure of these …