The COVID-19 immune landscape is dynamically and reversibly correlated with disease severity
BACKGROUND Despite a rapidly growing body of literature on coronavirus disease 2019
(COVID-19), our understanding of the immune correlates of disease severity, course, and …
(COVID-19), our understanding of the immune correlates of disease severity, course, and …
[HTML][HTML] Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions
COVID-19 has become a global pandemic. Immune dysregulation has been implicated, but
immune responses remain poorly understood. We analyzed 71 COVID-19 patients …
immune responses remain poorly understood. We analyzed 71 COVID-19 patients …
Multi-faceted dysregulated immune response for COVID-19 infection explaining clinical heterogeneity
SK Paine, P Choudhury, M Alam, C Bhattacharyya… - Cytokine, 2024 - Elsevier
Clinical heterogeneity and varied prognosis are well noted for SARS-CoV-2 infection.
Altered immune response is a major feature for the adverse prognosis however focus on …
Altered immune response is a major feature for the adverse prognosis however focus on …
Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19
NAF Janssen, I Grondman… - The Journal of …, 2021 - academic.oup.com
The clinical spectrum of COVID-19 varies and the differences in host response
characterizing this variation have not been fully elucidated. COVID-19 disease severity …
characterizing this variation have not been fully elucidated. COVID-19 disease severity …
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
The IMPACC cohort, composed of> 1,000 hospitalized COVID-19 participants, contains five
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …
[HTML][HTML] Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia
Immune profiling of COVID-19 patients has identified numerous alterations in both innate
and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or …
and adaptive immunity. However, whether those changes are specific to SARS-CoV-2 or …
Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection
L Kuri-Cervantes, MB Pampena, W Meng… - BioRxiv, 2020 - biorxiv.org
Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation,
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively …
Early stimulated immune responses predict clinical disease severity in hospitalized COVID-19 patients
Background The immune pathogenesis underlying the diverse clinical course of COVID-19
is poorly understood. Currently, there is an unmet need in daily clinical practice for early …
is poorly understood. Currently, there is an unmet need in daily clinical practice for early …
Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients
CE Burnett, TLH Okholm, I Tenvooren, DM Marquez… - Immunity, 2022 - cell.com
While studies have elucidated many pathophysiological elements of COVID-19, little is
known about immunological changes during COVID-19 resolution. We analyzed immune …
known about immunological changes during COVID-19 resolution. We analyzed immune …
Single-cell landscape of immunological responses in patients with COVID-19
Abstract In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …