Several studies implicated cyclic adenosine monophosphate (cAMP) as an important
second messenger for regulating nociceptor sensitization, but downstream targets of this …

There is emerging evidence that hyperpolarization-activated cation (HCN) channels are
involved in the development of pathological pain, including allodynia and hyperalgesia …

Nociceptor sensitization following nerve injury or inflammation leads to chronic pain. An
increase in the nociceptor hyperpolarization-activated current, Ih, is observed in many …

Neuropathic pain is a common and often incapacitating clinical problem for which little
useful therapy is presently available. Painful peripheral neuropathies can have many …

The Tac4 gene-derived hemokinin-1 (HK-1) is present in pain-related regions and activates
the tachykinin NK1 receptor, but with binding site and signaling pathways different from …

High-threshold nociceptor sensory neurons in the peripheral somatosensory nervous
system do not act as fixed detectors of external stimuli; instead, the sensitivity of their …

The cyclic nucleotide signaling, including cAMP-PKA and cGMP-PKG pathways, has been
well known to play critical roles in regulating cellular growth, metabolism and many other …

Nociception—the ability to detect painful stimuli—is an invaluable sense that warns against
present or imminent damage. In patients with chronic pain, however, this warning signal …

Abstract Background Unilateral injection of Complete Freund's Adjuvant (CFA) into the intra‐
plantar surface of the rodent hindpaw elicits chronic inflammation and hyperalgesia in the …

Inflammatory pain, characterized by a decrease in the nociceptive threshold, arises through
the actions of inflammatory mediators. Mitogen-activated protein kinase cascades participate …