Tip60-mediated H2A. Z acetylation promotes neuronal fate specification and bivalent gene activation
Cell lineage specification is accomplished by a concerted action of chromatin remodeling
and tissue-specific transcription factors. However, the mechanisms that induce and maintain …
and tissue-specific transcription factors. However, the mechanisms that induce and maintain …
A neuronal activity-dependent dual function chromatin-modifying complex regulates arc expression
NE Oey, HW Leung, R Ezhilarasan, L Zhou… - eneuro, 2015 - eneuro.org
Chromatin modification is an important epigenetic mechanism underlying neuroplasticity.
Histone methylation and acetylation have both been shown to modulate gene expression …
Histone methylation and acetylation have both been shown to modulate gene expression …
Microarray analysis uncovers a role for Tip60 in nervous system function and general metabolism
Background Tip60 is a key histone acetyltransferase (HAT) enzyme that plays a central role
in diverse biological processes critical for general cell function; however, the chromatin …
in diverse biological processes critical for general cell function; however, the chromatin …
A dual role of linker histone H1. 4 Lys 34 acetylation in transcriptional activation
K Kamieniarz, A Izzo, M Dundr… - Genes & …, 2012 - genesdev.cshlp.org
The linker histone H1 is a key player in chromatin organization, yet our understanding of the
regulation of H1 functions by post-translational modifications is very limited. We provide here …
regulation of H1 functions by post-translational modifications is very limited. We provide here …
Postmitotic accumulation of histone variant H3. 3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity
Histone variants, which can be expressed outside of S-phase and deposited DNA synthesis-
independently, provide long-term histone replacement in postmitotic cells, including …
independently, provide long-term histone replacement in postmitotic cells, including …
Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells
Lysine 56 acetylation in the helical core of histone H3 opens yeast chromatin and enables
histone gene transcription, DNA replication, and DNA repair and prevents epigenetic …
histone gene transcription, DNA replication, and DNA repair and prevents epigenetic …
Comprehensive benchmarking reveals H2BK20 acetylation as a distinctive signature of cell-state-specific enhancers and promoters
V Kumar, NA Rayan, M Muratani, S Lim… - Genome …, 2016 - genome.cshlp.org
Although over 35 different histone acetylation marks have been described, the
overwhelming majority of regulatory genomics studies focus exclusively on H3K27ac and …
overwhelming majority of regulatory genomics studies focus exclusively on H3K27ac and …
[HTML][HTML] Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7
In the conventional model of transcriptional activation, transcription factors bind to response
elements and recruit co-factors, including histone acetyltransferases. Contrary to this model …
elements and recruit co-factors, including histone acetyltransferases. Contrary to this model …
Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription
Post-translational modifications of proteins have emerged as a major mechanism for
regulating gene expression. However, our understanding of how histone modifications …
regulating gene expression. However, our understanding of how histone modifications …
A unique histone 3 lysine 14 chromatin signature underlies tissue-specific gene regulation
Organismal development and cell differentiation critically depend on chromatin state
transitions. However, certain developmentally regulated genes lack histone 3 lysine 9 and …
transitions. However, certain developmentally regulated genes lack histone 3 lysine 9 and …