Predicting cytokine storms: it's about density mosaicism for Hsa21, confirming that
phenotypically normal neonates with hematologic findings consistent with TMD should be …

In this issue of Blood, Wlodarski and colleagues demonstrate that as many as 72% of
adolescents diagnosed with myelodysplastic syndrome (MDS) and monosomy 7 harbor …

Children diagnosed with Down syndrome (DS) have a 150-fold increased risk of developing
a unique acute myeloid leukemia (ML-DS) within the first 4 years of life. 1, 2 ML-DS is …

Children with Down syndrome (DS) have a greater than 100-fold increased risk of
developing acute myeloid leukemia (ML) and an approximately 30-fold increased risk of …

Similarly to the leukemias of DS, sporadic childhood leukemias are initiated in utero.
Somatic structural or numerical chromosomal aberrations acquired in fetal hematopoietic …

Background Transient abnormal myelopoiesis (TAM) is a unique myeloproliferative disorder
that occurs in neonates with constitutional trisomy 21/Down syndrome (DS). Although TAM …

Transient abnormal myelopoiesis (TAM), a preleukemic disorder unique to neonates with
Down syndrome (DS), may transform to childhood acute myeloid leukemia (ML-DS) …

Children with Down syndrome exhibit 2 related hematopoietic diseases: transient
myeloproliferative disorder (TMD) and acute megakaryoblastic leukemia (AMKL). Both …

Introduction Accurate detection of GATA1 mutation is highly significant in patients with acute
myeloid leukemia (AML) and trisomy 21 as it allows optimization of clinical protocol. This …

Abstract Constitutional trisomy 21 (T21) is a state of aneuploidy associated with high
incidence of childhood acute myeloid leukemia (AML). T21-associated AML is preceded by …