Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia

S De Biasi, M Meschiari, L Gibellini, C Bellinazzi… - Nature …, 2020 - nature.com
The immune system of patients infected by SARS-CoV-2 is severely impaired. Detailed
investigation of T cells and cytokine production in patients affected by COVID-19 pneumonia …

Inflammatory cytokine: IL-17A signaling pathway in patients present with COVID-19 and current treatment strategy

T Shibabaw - Journal of inflammation research, 2020 - Taylor & Francis
Abstract Coronavirus disease 2019 (COVID-19) is a globally communicable public health
disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV-2) …

Remodeling of T cell dynamics during long COVID is dependent on severity of SARS-CoV-2 infection

M Wiech, P Chroscicki, J Swatler, D Stepnik… - Frontiers in …, 2022 - frontiersin.org
Several COVID-19 convalescents suffer from the post-acute COVID-syndrome (PACS)/long
COVID, with symptoms that include fatigue, dyspnea, pulmonary fibrosis, cognitive …

Longitudinal analysis of COVID-19 patients shows age-associated T cell changes independent of ongoing ill-health

L Townsend, AH Dyer, A Naughton, R Kiersey… - Frontiers in …, 2021 - frontiersin.org
Objectives The immunological and inflammatory changes following acute COVID-19 are
hugely variable. Persistent clinical symptoms following resolution of initial infection, termed …

T-helper cell subset response is a determining factor in COVID-19 progression

FJ Gil-Etayo, P Suàrez-Fernández… - Frontiers in cellular …, 2021 - frontiersin.org
The immune response type organized against viral infection is determinant in the prognosis
of some infections. This work has aimed to study Th polarization in acute COVID-19 and its …

Neutrophils mediate Th17 promotion in COVID-19 patients

Z Parackova, M Bloomfield, A Klocperk… - Journal of Leucocyte …, 2021 - academic.oup.com
From the beginning of 2020, an urgent need to understand the pathophysiology of SARS-
CoV-2 disease (COVID-19), much of which is due to dysbalanced immune responses …

The role of Th17 response in COVID-19

D Martonik, A Parfieniuk-Kowerda, M Rogalska… - Cells, 2021 - mdpi.com
COVID-19 is an acute infectious disease of the respiratory system caused by infection with
the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome Coronavirus 2). Transmission …

A case for targeting Th17 cells and IL-17A in SARS-CoV-2 infections

M Orlov, PL Wander, ED Morrell… - The Journal of …, 2020 - journals.aai.org
Abstract SARS-CoV-2, the virus causing COVID-19, has infected millions and has caused
hundreds of thousands of fatalities. Risk factors for critical illness from SARS-CoV-2 infection …

Reappearance of effector T cells is associated with recovery from COVID-19

I Odak, J Barros-Martins, B Bošnjak, K Stahl, S David… - …, 2020 - thelancet.com
Background Elucidating the role of T cell responses in COVID-19 is of utmost importance to
understand the clearance of SARS-CoV-2 infection. Methods 30 hospitalized COVID-19 …

Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients

J Westmeier, K Paniskaki, Z Karaköse, T Werner… - MBio, 2020 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell
response that most likely contributes to virus control in COVID-19 patients but may also …