Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer's disease

A Justin Thenmozhi, TR William Raja… - Nutritional …, 2017 - Taylor & Francis
Background/aims: Deregulation of metal ion homeostasis has been assumed as one of the
key factors in the progression of neurodegenerative diseases. Aluminium (Al) has been …

Neuroprotective effect of hesperidin on aluminium chloride induced Alzheimer's disease in Wistar rats

AJ Thenmozhi, TRW Raja, U Janakiraman… - Neurochemical …, 2015 - Springer
The present study was aimed to evaluate the protective effect of hesperidin (Hes) on
aluminium chloride (AlCl 3) induced neurobehavioral and pathological changes in …

Hypericum perforatum extract attenuates behavioral, biochemical, and neurochemical abnormalities in aluminum chloride-induced Alzheimer's disease rats

Z Cao, F Wang, C Xiu, J Zhang, Y Li - Biomedicine & pharmacotherapy, 2017 - Elsevier
Alzheimer's disease (AD) is a progressive and ultimately fatal neurodegenerative diseases.
Aluminum, a neurotoxic metal, is considered as the pathological hallmark and contributing …

Hesperidin and silibinin ameliorate aluminum-induced neurotoxicity: modulation of antioxidants and inflammatory cytokines level in mice hippocampus

A Jangra, P Kasbe, SN Pandey, S Dwivedi… - Biological trace element …, 2015 - Springer
Mounting evidence suggests that long-term aluminum exposure results in severe toxic
effects, including neurobehavioral and neurochemical anomalies. The present study was …

[HTML][HTML] Attenuation of aluminum chloride-induced neuroinflammation and caspase activation through the AKT/GSK-3β pathway by hesperidin in wistar rats

A Justin-Thenmozhi, M Dhivya Bharathi… - Neurotoxicity …, 2018 - Springer
Hesperidin, a flavanoglycone abundantly present in citrus fruits, is reported to have
antioxidant, anti-inflammatory, and neuroprotective properties. Previous reports from our …

Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid alteration in intracerebroventricular streptozotocin induced cognitive impairment …

H Javed, K Vaibhav, ME Ahmed, A Khan… - Journal of the …, 2015 - Elsevier
Recent attention is given to the influence of dietary supplementation on health and mental
well-being. Oxidative stress is associated with many diseases including neurodegenerative …

[HTML][HTML] Gallic acid and hesperidin elevate neurotransmitters level and protect against oxidative stress, inflammation and apoptosis in aluminum chloride-induced …

BE Ekundayo, TO Obafemi, BA Afolabi… - Pharmacological …, 2022 - Elsevier
Abstract Background/Aim Gallic acid and metformin are plant-derived compounds with
biological effects. The present study aimed to evaluate the protective effect of gallic acid and …

[PDF][PDF] Asiatic acid nullified aluminium toxicity in in vitro model of Alzheimer's disease

MA Rather, AJ Thenmozhi, T Manivasagam… - Front. Biosci …, 2018 - article.imrpress.com
Aluminium (Al) is a ubiquitously distributed environmental toxicant that lacks biological
functions; however, its accumulation in the brain has been demonstrated to be linked to …

Allicin ameliorates aluminium- and copper-induced cognitive dysfunction in Wistar rats: relevance to neuro-inflammation, neurotransmitters and Aβ(1–42) analysis

S Kaur, K Raj, YK Gupta, S Singh - JBIC Journal of Biological Inorganic …, 2021 - Springer
Alzheimer's disease (AD) is a multifactorial neurological disorder associated with
neuropathological and neurobehavioral changes, like cognition and memory loss …

Tannoid principles of Emblica officinalis renovate cognitive deficits and attenuate amyloid pathologies against aluminum chloride induced rat model of Alzheimer's …

A Justin Thenmozhi, M Dhivyabharathi… - Nutritional …, 2016 - Taylor & Francis
Background/aims: Emblica officinalis is mentioned as a maharasayana in many Ayurvedic
texts and promotes intelligence, memory, freedom from disease, longevity, and strength of …