The interaction of mesenchymal stem cells (MSCs) with endothelium in vivo is significant for
regenerative processes in organisms. To design concepts for tissue engineering for bone …

Adequate vascularization remains one of the major challenges in bone tissue engineering.
Since the microvascular endothelium is of benefit to osteogenesis and vascularization when …

Tissue engineering strategies often fail to regenerate bones because of inadequate
vascularization, especially in the reconstruction of large segmental bone defects. Large …

It is well established that vascularization is critical for osteogenesis. However, adequate
vascularization also remains one of the major challenges in tissue engineering of bone. This …

Background Improved understanding of the interactions between bone cells and endothelial
cells involved in osteogenesis should aid the development of new strategies for bone tissue …

Background and Aims Bone is a highly vascularized tissue reliant on the close spatial and
temporal connection between blood vessels and bone cells to maintain skeletal integrity …

Aim: The size of a bone defect limits the ingrowth of bone-forming cells. Endothelial cell–like
differentiated precursor cells (endothelial progenitor cells, EPC) enhance the …

Although studies in vivo revealed promising results in bone regeneration after implantation
of scaffolds together with osteogenic progenitor cells, basic questions remain how material …

In this work, human mesenchymal stem cells (hMSCs) and their osteogenically precultured
derivatives were directly cocultured with human umbilical vein endothelial cells (HUVECs) …

To optimize culture conditions for in vitro prevascularization of tissue-engineered bone
constructs, the development of organotypic blood vessels under osteogenic stimulatory …