Hepatocellular carcinoma (HCC) is the fifth most common solid tumor in the world and the
third leading cause of cancer-associated deaths. A Sleeping Beauty-mediated transposon …

The Sleeping Beauty (SB) transposon mutagenesis system is a powerful tool that facilitates
the discovery of mutations that accelerate tumorigenesis. In this study, we sought to identify …

Steroid receptor coactivator 1 (SRC-1) is a transcriptional coactivator not only for steroid
receptors, such as androgen receptor and estrogen receptor, but also for other transcription …

Steroid receptor coactivator-1 (SRC-1) is a coactivator for nuclear hormone receptors such
as estrogen and progesterone receptors and certain other transcription factors such as Ets-2 …

Background/Aim: Dysregulation of the c-Myc gene is frequently found in human
hepatocellular carcinoma (HCC), often accompanied by genetic and epigenetic alterations …

Prostate cancer is the most common cancer in men in America. Currently, steroid receptor
coactivators have been proposed to mediate the development and progression of prostate …

CSCs (Cancer stem cells) with distinct metabolic features are considered to cause HCC
(hepatocellular carcinoma) initiation, metastasis and therapeutic resistance. Here, we …

Objectives Although c-Src (Src) has emerged as a potential pancreatic cancer target in
preclinical studies, Src inhibitors have not demonstrated a significant therapeutic benefit in …

Deregulated activity of the c-Myc protooncogene is a frequent molecular event underlying
mouse and human hepatocarcinogenesis. Nonetheless, the mechanisms sustaining c-Myc …

The MYC oncogene is often dysregulated in human cancer, including hepatocellular
carcinoma (HCC). MYC is considered undruggable to date. Here, we comprehensively …