Fungal species have the capability of producing an overwhelming diversity of bioactive
substances that can have beneficial but also detrimental effects on human health. These so …

Recent advancements in genome sequencing and bioinformatic analysis of fungal genomes
have revealed that fungi possess cryptic or silent biosynthetic gene clusters (BGCs). This …

Highlights•Fungi are an excellent source of drugs, and their full potential in producing
different metabolites is still largely untapped.•Several heterologous platforms have been …

There is an urgent need to diversify the pipeline for discovering novel natural products due
to the increase in multi-drug resistant infections. Like bacteria, fungi also produce secondary …

Mining for novel natural compounds is of eminent importance owing to the continuous need
for new pharmaceuticals. Filamentous fungi are historically known to harbor the genetic …

Fungal natural products possess biological activities that are of great value to medicine,
agriculture and manufacturing. Recent metagenomic studies accentuate the vastness of …

Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …

Bioprospecting of natural sources for new medicines has a long and successful history,
exemplified by the fact that over 50% of all drugs currently on the market are either derived …

Microorganisms produce a wide range of natural products (NPs) with clinically and
agriculturally relevant biological activities. In bacteria and fungi, genes encoding successive …

Fungal secondary metabolites (SMs) represent an invaluable source of therapeutic drugs.
Genomics-based approaches to SM discovery have revealed a vast and largely untapped …