Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-
19, but the mechanisms involved remain poorly understood. We carried out proteomic …

Mechanisms of neutrophil involvement in severe coronavirus disease 2019 (COVID-19)
remain incompletely understood. Here, we collect longitudinal blood samples from 306 …

Whilst the majority of individuals infected with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, experience mild to …

A maladaptive inflammatory response has been implicated in the pathogenesis of severe
COVID-19. This study aimed to characterize the temporal dynamics of this response and …

Objectives Critical illness in COVID-19 is attributed to an exaggerated host immune
response. Since neutrophils are the major component of innate immunity, we hypothesize …

Background Increased inflammation has been well defined in coronavirus disease 2019
(COVID-19), while definitive pathways driving severe forms of this disease remain uncertain …

Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …

Background COVID19 is caused by the SARS-CoV-2 virus and has been associated with
severe inflammation leading to organ dysfunction and mortality. Our aim was to profile the …

The COVID-19 pandemic is progressing worldwide with an alarming death toll. There is an
urgent need for novel therapeutic strategies to combat potentially fatal complications …

Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the
triggering of an aberrant host immune response, more so than on direct virus-induced …