Nicotinic acetylcholine receptors (AChRs) are one of the best characterized ion channels
from the Cys-loop receptor superfamily. The study of acetylcholine binding proteins and …

Nicotinic acetylcholine receptors are pentameric proteins that belong to the Cys-loop
receptor superfamily. Their essential mechanism of functioning is to couple neurotransmitter …

Nicotinic acetylcholine receptors (nAChRs) are in the superfamily of cys‐loop receptors, and
are widely expressed in the nervous system where they participate in a variety of …

Nicotinic receptors are membrane proteins involved in several physiological processes.
They are considered suitable drug targets for various CNS disorders or conditions, as shown …

The nicotinic acetylcholine receptor (AChR) presents two very well differentiated domains for
ligand binding that account for different cholinergic properties. In the hydrophilic …

The nicotinic acetylcholine (ACh) receptors and the other neurotransmitter-gated ion
channels have key roles in fast synaptic transmission throughout the nervous system. These …

Positive allosteric modulators (PAMs), negative allosteric modulators (NAMs), silent
agonists, allosteric activating PAMs and neutral or silent allosteric modulators are …

The nicotinic acetylcholine (ACh) receptor belongs to a superfamily of synaptic ion channels
that open in response to the binding of chemical transmitters. Their mechanism of activation …

Postsynaptic nAChRs in the peripheral nervous system are critical for neuromuscular and
autonomic neurotransmission. Pre-and peri-synaptic nAChRs in the brain modulate …

Over the last two decades a convergence of techniques from various scientific disciplines
has led to enormous growth in our comprehension of the structure, evolutionary trends and …