Background Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor, which
activates the anti-oxidative stress response pathway. In epilepsy, oxidative stress is one of …

Objective Role of apoptosis and neuroinflammation have been well established in the
pathogenesis of epilepsy. It has been reported that the activation of nuclear factor-erythroid …

ABSTRACT Purpose/Aim: Epilepsy is a complex, chronic neurological disorder
characterized by increased and abnormal synchronization of neuronal electrical activity …

Oxidative stress resulting from excessive free-radical release is likely implicated in the
initiation and progression of epilepsy. Therefore, antioxidant therapies have received …

Epilepsy remains a major medical problem for which there is no effective treatment.
Oxidative damage plays an important role in epilepsy pathogenesis and may represent a …

Epilepsy is a neurodegenerative brain disorder characterized by recurrent seizure attacks.
Numerous studies have suggested a strong correlation between oxidative stress and …

Background Epilepsy affects over 65 million people worldwide and significantly burdens
patients, caregivers, and society. Drug-resistant epilepsy occurs in approximately 30% of …

Methods Kindling has been induced in all groups, except for the control group via 11 PTZ
injections (35 mg/kg; ip) every other day for 22 days. In the 24th day, the PTZ challenge dose …

Evidence points towards oxidative stress and neuroinflammation being major processes
associated with brain dysfunction in epilepsy. Salidroside reportedly possesses anti …

Aims Some conventional antiepileptic drugs induce oxidative stress and cognitive
impairment which may limit their clinical applications. Ferulic acid is a phenolic …