Intrinsically disordered (ID) regions are disproportionately higher in cell signaling proteins
and are predicted to have much larger frequency of phosphorylation sites than ordered …

Intrinsically disordered (ID) regions of the transcription factor proteins have much larger
frequency of phosphorylation sites than ordered regions, suggesting an important role in …

Protein phosphorylation often switches cellular activity from one state to another, and this
post-translational modification plays an important role in gene regulation by the nuclear …

Intrinsically disordered (ID) regions of proteins commonly exist within transcription factors,
including the N-terminal domain (NTD) of steroid hormone receptors (SHRs) that possesses …

Intrinsically disordered (ID) sequence segments are abundant in cell signaling proteins and
transcription factors. Because ID regions commonly fold as part of their intracellular function …

Intrinsically disordered (ID) regions are frequently found in the activation domains of many
transcription factors including nuclear hormone receptors. It is believed that these ID regions …

Intrinsically disordered proteins (IDPs) present a functional paradox because they lack
stable tertiary structure, but nonetheless play a central role in signaling, utilizing a process …

The glucocorticoid receptor (GR) mediates biological effects of glucocorticoids at the level of
gene regulation, and plays important roles in many aspects of physiology. In recent years, it …

Allostery is a biological phenomenon of critical importance in metabolic regulation and cell
signalling. The fundamental premise of classical models that describe allostery is that …

Control of gene transcription by glucocorticoid receptors (GRs) is important for many
physiological processes. Like other steroid hormone receptors, the regulation of target …