WebQTL: rapid exploratory analysis of gene expression and genetic networks for brain and behavior

EJ Chesler, L Lu, J Wang, RW Williams… - Nature neuroscience, 2004 - nature.com
WebQTL. The abundance of Grin2b mRNA transcript in several forebrain data sets varies
approximately two-fold across 35 strains. Half of the variation in expression is heritable; and …

A glimmer of light for neuropsychiatric disorders.

SE Hyman - Nature, 2008 - nature.com
Understanding the pathogenesis of neuropsychiatric disorders is a substantial challenge for
neurobiologists. It has long been hoped that identifying alleles that confer increased risk of …

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Indonesia Schizophrenia Consortium… - Nature, 2022 - research.vu.nl
Schizophrenia has a heritability of 60-80% 1, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

V Trubetskoy, AF Pardiñas, T Qi, G Panagiotaropoulou… - Nature, 2022 - nature.com
Schizophrenia has a heritability of 60–80%, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

Genes, brain and cognition

R Plomin, SM Kosslyn - Nature neuroscience, 2001 - nature.com
Genes, brain and cognition | Nature Neuroscience Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

WebQTL: web-based complex trait analysis

J Wang, RW Williams, KF Manly - Neuroinformatics, 2003 - Springer
WebQTL is a website that combines databases of complex traits with fast software for
mapping quantitative trait loci (QTLs) and for searching for correlations among traits …

Rare coding variants in ten genes confer substantial risk for schizophrenia

T Singh, T Poterba, D Curtis, H Akil, M Al Eissa… - Nature, 2022 - nature.com
Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

Emerging phenotyping strategies will advance our understanding of psychiatric genetics

S Sanchez-Roige, AA Palmer - Nature neuroscience, 2020 - nature.com
Over the last decade, genome-wide association studies of psychiatric disorders have
identified numerous significant loci. Whereas these studies initially depended on cohorts …

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

RK Walters, R Polimanti, EC Johnson… - Nature …, 2018 - nature.com
Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …

An anatomically comprehensive atlas of the adult human brain transcriptome

MJ Hawrylycz, ES Lein, AL Guillozet-Bongaarts… - Nature, 2012 - nature.com
Neuroanatomically precise, genome-wide maps of transcript distributions are critical
resources to complement genomic sequence data and to correlate functional and genetic …