Immunogenicity of clinically relevant SARS-CoV-2 vaccines in nonhuman primates and humans

PJ Klasse, DF Nixon, JP Moore - Science advances, 2021 - science.org
Multiple preventive vaccines are being developed to counter the coronavirus disease 2019
pandemic. The leading candidates have now been evaluated in nonhuman primates (NHPs) …

Progress and pitfalls in the quest for effective SARS-CoV-2 (COVID-19) vaccines

KL Flanagan, E Best, NW Crawford, M Giles… - Frontiers in …, 2020 - frontiersin.org
There are currently around 200 SARS-CoV-2 candidate vaccines in preclinical and clinical
trials throughout the world. The various candidates employ a range of vaccine strategies …

Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

KS Corbett, MC Nason, B Flach, M Gagne, S O'Connell… - Science, 2021 - science.org
INTRODUCTION Mass vaccination against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) offers the most efficient public health intervention to control the COVID-19 …

Approaches and challenges in SARS-CoV-2 vaccine development

G Dagotto, J Yu, DH Barouch - Cell host & microbe, 2020 - cell.com
The explosive spread of SARS-CoV-2 suggests that a vaccine will be required to end this
global pandemic. Progress in SARS-CoV-2 vaccine development to date has been faster …

[HTML][HTML] SARS-CoV-2 vaccines in advanced clinical trials: Where do we stand?

S Chakraborty, V Mallajosyula, CM Tato, GS Tan… - Advanced drug delivery …, 2021 - Elsevier
The ongoing SARS-CoV-2 pandemic has led to the focused application of resources and
scientific expertise toward the goal of developing investigational vaccines to prevent COVID …

Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models

DS Khoury, AK Wheatley, MD Ramuta… - Nature Reviews …, 2020 - nature.com
The rapid scale-up of research on coronavirus disease 2019 (COVID-19) has spawned a
large number of potential vaccines and immunotherapies, accompanied by a …

Comparison of the immunogenicity & protective efficacy of various SARS-CoV-2 vaccine candidates in non-human primates

L Mukhopadhyay, PD Yadav, N Gupta… - Indian Journal of …, 2021 - journals.lww.com
Methods: Literature on effect of SARS-CoV-2 vaccines in NHP models reported on PubMed
and preprint platforms (medRxiv and bioRxiv) till October 22, 2020, was searched with the …

SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates

GA Poland, IG Ovsyannikova, RB Kennedy - The Lancet, 2020 - thelancet.com
Understanding immune responses to severe acute respiratory syndrome coronavirus 2 is
crucial to understanding disease pathogenesis and the usefulness of bridge therapies, such …

COVID-19 vaccines:“Warp Speed” needs mind melds, not warped minds

JP Moore, PJ Klasse - Journal of virology, 2020 - Am Soc Microbiol
In this review, we address issues that relate to the rapid “Warp Speed” development of
vaccines to counter the COVID-19 pandemic. We review the antibody response that is …

COVID-19: Mechanisms of vaccination and immunity

DE Speiser, MF Bachmann - Vaccines, 2020 - mdpi.com
Vaccines are needed to protect from SARS-CoV-2, the virus causing COVID-19. Vaccines
that induce large quantities of high affinity virus-neutralizing antibodies may optimally …