The first line of defense against viral infections is mediated by interferons (IFN) s, which are
produced rapidly by the infected host. Type I IFNs (IFN-α/β) are known to combat viruses …

Interferons (IFNs) can serve as the first line of immune defense against viral infection. The
identification of IFN-λs 1, 2, 3 & 4 (termed as type III IFNs) has revealed that the antiviral …

For decades, type I IFNs have been considered indispensable and unique antiviral
mediators for the activation of rapid innate antiviral protection. However, the recent discovery …

Type III interferons (IFNs)(interleukin-28/29 or lambda interferon [IFN-λ]) are cytokines with
IFN-like activities. Here we show that several classes of viruses induce expression of IFN-λ1 …

Cytokines are small secreted molecules, which mediate cross‐talk between cells involved in
the immune response. Interferons (IFN) s, constitute a class of cytokines with antiviral …

The discovery and initial description of the interferon-λ (IFN-λ) family in early 2003 opened
an exciting new chapter in the field of IFN research. There are 3 IFN-λ genes that encode 3 …

Abstract Type III IFNs (IFN-λ/IL-28/29) are cytokines with type I IFN-like antiviral activities,
which remain poorly characterized. We herein show that most cell types expressed both …

Interferons (IFNs) are key cytokines in the establishment of a multifaceted antiviral response.
hree distinct types of IFNs are now recognized (type I, type II, and type III) based on their …

Virus replication induces the expression of antiviral type I (IFN-αβ) and type III (IFN-λ1–3 or
IL-28A/B and IL-29) IFN genes via TLR-dependent and-independent pathways. Although …

With increasing interest in alternative options to interferon‐alpha‐based treatments, IFN‐λ
has shown therapeutic promise in a variety of diseases. Although the antiviral activity of IFN …