Foreground contextual fear memory consolidation requires two independent phases of hippocampal ERK/CREB activation

P Trifilieff, C Herry, P Vanhoutte, J Caboche… - Learning & …, 2006 - learnmem.cshlp.org
Fear conditioning is a popular model for investigating physiological and cellular
mechanisms of memory formation. In this paradigm, a footshock is either systematically …

Biphasic ERK1/2 activation in both the hippocampus and amygdala may reveal a system consolidation of contextual fear memory

P Trifilieff, L Calandreau, C Herry, N Mons… - Neurobiology of learning …, 2007 - Elsevier
There is accumulating evidences to suggest that memory consolidation in some conditions
involves two waves of neuronal plastic change. Using two fear conditioning procedures in …

Brain region-specific gene expression activation required for reconsolidation and extinction of contextual fear memory

N Mamiya, H Fukushima, A Suzuki… - Journal of …, 2009 - Soc Neuroscience
During fear conditioning, animals learn an association between a previously neutral or
conditioned stimulus (CS) and an aversive or unconditioned stimulus (US). Subsequent …

A thalamic-hippocampal CA1 signal for contextual fear memory suppression, extinction, and discrimination

HC Ratigan, S Krishnan, S Smith… - Nature …, 2023 - nature.com
The adaptive regulation of fear memories is a crucial neural function that prevents
inappropriate fear expression. Fear memories can be acquired through contextual fear …

Segregated populations of hippocampal principal CA1 neurons mediating conditioning and extinction of contextual fear

NC Tronson, C Schrick, YF Guzman… - Journal of …, 2009 - Soc Neuroscience
Learning processes mediating conditioning and extinction of contextual fear require
activation of several key signaling pathways in the hippocampus. Principal hippocampal …

Resistance to extinction is associated with impaired immediate early gene induction in medial prefrontal cortex and amygdala

C Herry, N Mons - European Journal of Neuroscience, 2004 - Wiley Online Library
Extinction of classical fear conditioning is thought to involve activity‐dependent potentiation
of synaptic transmission in the medial prefrontal cortex (mPFC), resulting in the inhibition of …

The hippocampus integrates context and shock into a configural memory in contextual fear conditioning

SD Chang, KC Liang - Hippocampus, 2017 - Wiley Online Library
Contextual fear conditioning involves forming a representation for the context and
associating it with a shock, which were attributed by the prevailing view to functions of the …

Comparative dynamics of MAPK/ERK signalling components and immediate early genes in the hippocampus and amygdala following contextual fear conditioning and …

B Antoine, L Serge, C Jocelyne - Brain Structure and Function, 2014 - Springer
Over the past few years multiple studies have attempted to uncover molecular signatures of
memory reconsolidation when compared to consolidation. In the present study we used …

Ensemble coding of context-dependent fear memory in the amygdala

CA Orsini, C Yan, S Maren - Frontiers in behavioral neuroscience, 2013 - frontiersin.org
After fear conditioning, presenting the conditioned stimulus (CS) alone yields a context-
specific extinction memory; fear is suppressed in the extinction context, but renews in any …

Egr-1 increases in the prefrontal cortex following training in the context preexposure facilitation effect (CPFE) paradigm

A Asok, WB Schreiber, SA Jablonski, JB Rosen… - Neurobiology of learning …, 2013 - Elsevier
The context pre-exposure facilitation effect (CPFE) is a modified form of standard contextual
fear conditioning that dissociates learning about the context during a preexposure phase …