Simple Summary Omics technologies and targeted drugs are revolutionizing the clinical
oncology landscape, portending the promise of precision oncology. However, our abilities to …

Cancer is a complex and heterogeneous disease, demonstrating variations with respect to
tumor types and between individual tumors. This heterogeneity has complicated the search …

Traditionally, scientific research has focused on studying individual events, such as single
mutations, gene function, or the effect that mutating one protein has on a biological …

The development of cost-effective technologies able to comprehensively assess DNA, RNA,
protein, and metabolites in patient tumors has fueled efforts to tailor medical care. Indeed …

Current cancer therapies target a limited set of tumor features, rather than considering the
tumor as a whole. Systems biology aims to reveal therapeutic targets associated with a …

Current and emerging biomedical science efforts are driven by determining how to improve
clinical outcomes for patients, but the roadmap to achieve this goal has been controversial …

The identification of “driver mutations” in cancers initiated rapid development of targeted
drugs for the clinic. Despite promising outcomes initially in patients, the ultimate success of …

Cancer encompasses a complex, heterogeneous and dynamic group of diseases that arise
from perturbations to multiple biological networks within the body. A systems biology-based …

Cancer is now appreciated as not only a highly heterogenous pathology with respect to cell
type and tissue origin but also as a disease involving dysregulation of multiple pathways …

With over two hundred types of cancer diagnosed to date, researchers the world over have
been forced to rapidly update their understanding of the biology of cancer. In fact, only the …