Background Transcription regulation in pluripotent embryonic stem (ES) cells is a complex
process that involves multitude of regulatory layers, one of which is post-translational …

Epigenetic marks are important factors regulating the pluripotency and differentiation of
human embryonic stem cells (hESCs). In this study, we analyzed H3K9 acetylation, an …

Compared with histone H3, acetylation of H4 tails has not been well studied, especially in
mammalian cells. Yet, H4K16 acetylation is of particular interest because of its ability to …

Lysine 56 acetylation in the helical core of histone H3 opens yeast chromatin and enables
histone gene transcription, DNA replication, and DNA repair and prevents epigenetic …

Embryonic stem cell (ESC) chromatin is characterized by a unique set of histone
modifications, including enrichment for H3 lysine 9 acetylation (H3K9ac). Recent studies …

H3K27ac is well recognized as a marker for active enhancers and a great indicator of
enhancer activity. However, its functional impact on transcription has not been …

Early neurodevelopment requires cell fate commitment from pluripotent stem cells to
restricted neural lineages, which involves the epigenetic regulation of chromatin structure …

It remains poorly understood about the regulation of gene and transposon transcription
during human early embryogenesis. Here, we report that broad H3K27ac domains are …

Background Epigenetic mechanisms regulate gene expression patterns affecting cell
function and differentiation. In this report, we examine the role of histone acetylation in gene …

We mapped Polycomb-associated H3K27 trimethylation (H3K27me3) and Trithorax-
associated H3K4 trimethylation (H3K4me3) across the whole genome in human embryonic …