Melanins are ubiquitous catecholic pigments, formed in organelles called melanosomes
within melanocytes, the function of which is to protect skin against harmful effects of UV …

Melanoma cells have a poor ability to mediate oxidative stress, which may be attributed to
constitutive abnormalities in their melanosomes. We hypothesize that disorganization of the …

Epidermal melanocytes are particularly vulnerable to oxidative stress owing to the pro-
oxidant state generated during melanin synthesis, and to the intrinsic antioxidant defenses …

Certain aspects of current progress in melanin biology and its possible clinical relevances
are reviewed with emphasis on some of our recent research activities. The important aspects …

Melanin in the human retinal pigment epithelium (RPE) is believed to play an important
photoprotective role. However, unlike in skin, melanosomes in the RPE are rather long‐lived …

Melanosomes were recently shown to protect ARPE‐19 cells, a human retinal pigment
epithelium (RPE) cell line, against oxidative stress induced by hydrogen peroxide. One …

The human melanocyte is continuously exposed to intrinsic and extrinsic sources of reactive
biochemical species, but is finely tuned via the intrinsic anti‐oxidant and radical properties of …

The high number of somatic mutations in the melanoma genome associated with cumulative
ultra violet (UV) exposure has rendered it one of the most difficult of cancers to treat. With …

Melanoma has traditionally been viewed as an ultraviolet (UV) radiation‐induced
malignancy. While UV is a common inducing factor, other endogenous stresses such as …

Melanin synthesis is an oxygen‐dependent process that acts as a potential source of
reactive oxygen species (ROS) inside pigment‐forming cells. The synthesis of the lighter …