The thymus' key function in the immune system is to provide the necessary environment for
the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests …

The thymus is an intricate primary lymphoid organ, wherein bone marrow–derived lymphoid
progenitor cells are induced to develop into functionally competent T cells that express a …

T-cell development in the thymus is a stepwise process, mediated by a variety of stromal
cells in different regions of the organ. Although the cellular composition of the thymic …

Invariant natural killer T (iNKT), mucosal-associated invariant T (MAIT), and γδ T cells are
innate T cells that acquire memory phenotype in the thymus and share similar biological …

The thymus supports the production of self‐tolerant T cells from immature precursors.
Studying the mechanisms regulating the establishment and maintenance of stromal …

The thymus is a complex epithelial organ in which thymocyte development is dependent
upon the sequential contribution of morphologically and phenotypically distinct stromal cell …

Age-associated thymic involution results in diminished T cell output and function in aged
individuals. However, molecular mediators contributing to the decline in thymic function …

INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor
(TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell …

T cell development and selection are coordinated in the thymus by a specialized niche of
diverse stromal populations,–. Although much progress has been made over the years in …

Abstract Development of immunocompetent T cells in the thymus is required for effective
defence against all types of pathogens, including viruses, bacteria and fungi. To this end, T …