Abstract Coronavirus disease 2019 (COVID-19), the disease caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was identified in
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …

Abstract Coronavirus disease of 2019 (COVID-19) is a highly contagious respiratory
infection that is caused by the severe acute respiratory syndrome coronavirus 2. Although …

A novel coronavirus, SARS‐CoV‐2, has recently emerged in China and spread
internationally, posing a health emergency to the global community. COVID‐19 caused by …

Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …

Complement activation has been implicated in the pathogenesis of severe SARS-CoV-2
infection. However, it remains to be determined whether increased complement activation is …

Complement is integral to a healthy functioning immune system and orchestrates various
innate and adaptive responses against viruses and other pathogens. Despite its importance …

In a stunningly short period of time, the unexpected coronavirus disease 2019 (COVID-19)
pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2), has …

Acute respiratory failure and a systemic coagulopathy are critical aspects of the morbidity
and mortality characterizing infection with severe acute respiratory distress syndrome …

COVID‐19 is a complex disease manifesting in a broad severity spectrum and involving
distinct organs and systems. Hyperinflammation, including complement over‐activation, has …