Multiple on-line active valves based centrifugal microfluidics for dynamic solid-phase enrichment and purification of viral nucleic acid

S Li, C Wan, Y Xiao, C Liu, X Zhao, Y Zhang, H Yuan… - Lab on a Chip, 2024 - pubs.rsc.org
Point of care testing (POCT) of nucleic acids holds significant importance in the realm of
infectious disease prevention and control, as well as the advancement of personalized …

Fully integrated and automated centrifugal microfluidic chip for point-of-care multiplexed molecular diagnostics

Y Xiao, M Zhou, C Liu, S Gao, C Wan, S Li… - Biosensors and …, 2024 - Elsevier
Public health events caused by pathogens have imposed significant economic and societal
burdens. However, conventional methods still face challenges including complex …

A sample-to-answer, quantitative real-time PCR system with low-cost, gravity-driven microfluidic cartridge for rapid detection of SARS-CoV-2, influenza A/B, and …

Y Zai, C Min, Z Wang, Y Ding, H Zhao, E Su, N He - Lab on a Chip, 2022 - pubs.rsc.org
The pandemic of coronavirus disease 2019 (COVID-19), due to the novel coronavirus
(SARS-CoV-2), has created an unprecedented threat to the global health system, especially …

An integrated microfluidic chip for nucleic acid extraction and continued cdPCR detection of pathogens

Y Huang, Z Gao, C Ma, Y Sun, Y Huang, C Jia, J Zhao… - Analyst, 2023 - pubs.rsc.org
This paper introduces an enclosed microfluidic chip that integrates sample preparation and
the chamber-based digital polymerase chain reaction (cdPCR). The sample preparation of …

Integrated High-Throughput Centrifugal Microfluidic Chip Device for Pathogen Detection On-Site

S Lu, Y Yang, S Cui, A Li, C Qian, X Li - Biosensors, 2024 - mdpi.com
An integrated and high-throughput device for pathogen detection is crucial in point-of-care
testing (POCT), especially for early diagnosis of infectious diseases and preventing the …

An integrated microfluidic platform for nucleic acid testing

A Sun, P Vopařilová, X Liu, B Kou, T Řezníček… - Microsystems & …, 2024 - nature.com
This study presents a rapid and versatile low-cost sample-to-answer system for SARS-CoV-
2 diagnostics. The system integrates the extraction and purification of nucleic acids, followed …

Fluidic handling system for PCR-based sample-to-answer detection of viral nucleic acids

I Seder, DM Kim, SH Hwang, H Sung, DE Kim… - Sensors and Actuators B …, 2021 - Elsevier
Sample-to-answer detection of a viral infectious disease is becoming increasingly important
to prevent pandemic outbreaks. However, only a few microfluidic chips that use nucleic acid …

Simultaneous Rapid Nucleic Acid and Protein Detection in a Lateral Chromatography Chip for COVID-19 Diagnosis

Q Lin, J Zhang, L Liu, J Kong, X Fang - ACS omega, 2022 - ACS Publications
In this work, we report a fast, portable, and economical microfluidic platform for the
simultaneous detection of nucleic acid and proteins. Using SARS-CoV-2 as a target, this …

Multiplexed centrifugal microfluidic system for dynamic solid-phase purification of polynucleic acids direct from buccal swabs

LM Dignan, MS Woolf, CJ Tomley… - Analytical …, 2021 - ACS Publications
This report describes the development of a centrifugally controlled microfluidic dynamic solid-
phase extraction (dSPE) platform to reliably obtain amplification-ready nucleic acids (NAs) …

Smartphone operable centrifugal system (SOCS) for on-site DNA extraction from foodborne bacterial pathogen

SW Jeong, YM Park, SH Jo, SJ Lee, YT Kim, KG Lee - Biomicrofluidics, 2019 - pubs.aip.org
The on-site recovery of nucleic acid from foodborne bacteria is in high demand to further
understand on-site molecular diagnosis, which is especially applicable in developing …