AZD4547 targets the FGFR/Akt/SOX2 axis to overcome paclitaxel resistance in head and neck cancer
Purpose Development of chemoresistance is one of the major obstacles to the treatment of
head and neck squamous cell carcinoma (HNSCC). The PI3K/Akt pathway, involved in drug …
head and neck squamous cell carcinoma (HNSCC). The PI3K/Akt pathway, involved in drug …
[HTML][HTML] FGFR signaling regulates resistance of head and neck cancer stem cells to cisplatin
SC McDermott, C Rodriguez-Ramirez, SP McDermott… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC)
have poor prognosis with less than 1-year median survival. Platinum-based chemotherapy …
have poor prognosis with less than 1-year median survival. Platinum-based chemotherapy …
Gossypol reduces metastasis and epithelial-mesenchymal transition by targeting protease in human cervical cancer
YS Hsieh, SC Chu, SC Huang, SH Kao… - The American Journal …, 2021 - World Scientific
Metastasis is the most prevalent cause of cancer-associated deaths amongst patients with
cervical cancer. Epithelial–mesenchymal transition (EMT) is essential for carcinogenesis …
cervical cancer. Epithelial–mesenchymal transition (EMT) is essential for carcinogenesis …
Single-cell transcriptome analyses reveal molecular signals to intrinsic and acquired paclitaxel resistance in esophageal squamous cancer cells
Paclitaxel is widely used in the combination chemotherapy for many cancers including
esophageal squamous cell carcinoma (ESCC). However, the paclitaxel resistance occurs …
esophageal squamous cell carcinoma (ESCC). However, the paclitaxel resistance occurs …
Efficacy and safety of paclitaxel combined with cetuximab for head and neck squamous cell carcinoma
T Okada, I Okamoto, H Sato, T Ito, K Miyake… - in vivo, 2021 - iv.iiarjournals.org
Background/Aim: For recurrent/metastatic squamous cell carcinoma of the head and neck
(R/M SCCHN), popular regimens containing platinum-based anticancer agents and immune …
(R/M SCCHN), popular regimens containing platinum-based anticancer agents and immune …
Evaluation of tyrosine receptor kinases in the interactions of head and neck squamous cell carcinoma cells and fibroblasts
L Sweeny, TM Zimmermann, Z Liu, EL Rosenthal - Oral oncology, 2012 - Elsevier
Objective Despite treatment advancements, disease-free survival of head and neck
squamous cell carcinoma (HNSCC) has not significantly improved. This may be a result of …
squamous cell carcinoma (HNSCC) has not significantly improved. This may be a result of …
A randomized, phase 2 trial of docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic …
Introduction The phosphotidylinositol-3 kinase (PI3K)/serine–threonine kinase
(AKT)/mammalian target of rapamycin (mTOR) signaling pathway is frequently altered in …
(AKT)/mammalian target of rapamycin (mTOR) signaling pathway is frequently altered in …
[HTML][HTML] Synergistic cytotoxicity of cisplatin and Taxol in overcoming Taxol resistance through the inhibition of LDHA in oral squamous cell carcinoma
L Feng, MM Soloveiv, DS Wang… - Oncology …, 2015 - spandidos-publications.com
The development of chemoresistance in patients represents a major challenge in cancer
treatment. Lactate dehydrogenase‑A (LDHA) is one of the principle isoforms of LDH that is …
treatment. Lactate dehydrogenase‑A (LDHA) is one of the principle isoforms of LDH that is …
[HTML][HTML] New advances into cisplatin resistance in head and neck squamous carcinoma: mechanisms and therapeutic aspects
H Hu, B Li, J Wang, Y Tan, M Xu, W Xu, H Lu - Biomedicine & …, 2023 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) arises from the interplay of multiple
factors, such as smoking, alcohol consumption, and viral infections. Cisplatin-based …
factors, such as smoking, alcohol consumption, and viral infections. Cisplatin-based …
[HTML][HTML] Epigallocatechin-3-gallate attenuates head and neck cancer stem cell traits through suppression of Notch pathway
SH Lee, HJ Nam, HJ Kang, HW Kwon… - European journal of cancer, 2013 - Elsevier
Most solid cancers including head and neck squamous carcinoma (HNSC) are believed to
be initiated from and maintained by cancer stem cells (CSCs) that are responsible for …
be initiated from and maintained by cancer stem cells (CSCs) that are responsible for …